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Articles Posted by Malvern Instruments

Towards a Condensed Platform for Protein Aggregation Profiling

Published: December 4 2017

Malvern Panalytical wins Innovate UK grant to lead biopharmaceutical consortium on aggregation analytics   Malvern Panalytical announces the launch of a collaborative project which aims to support the development of existing and next

How Malvern Panalytical helped Rutgers University optimize their polymer scaffold fabrication processes for tissue engineering

Published: October 23 2017

Sanjeeva Murthy from the New Jersey center for Biomaterials explains why a capillary rheometer is a key piece of equipment for a polymer processing laboratory. Find out why New Jersey Center for Biomaterials at Rutgers University chose a Rosand

Understanding and minimizing polycaprolactone degradation during processing using multi-detector GPC and rheology

Published: October 12 2017

Malvern measures degradation related changes in molecular weight and rheology during polycaprolactone processing   Polycaprolactone (PCL) is a synthetic polymer that has recently received increasing attention thanks to its

Optimizing metal powders for additive manufacturing

Published: October 12 2017

Exploring the impact of particle morphology and powder flowability with Malvern. AM offers certain specific advantages relative to alternative powder metallurgy methods, ranging from design flexibility to the potential for high material use

Measuring the rheology of thermoplastic polymer melts

Published: October 12 2017

Malvern uses rotational and capillary rheometry to characterize polymer melts   Rheology is the science of studying the flow and deformation of materials rooted in the laws of elasticity and viscosity proposed by Hooke and Newton in the

Establishing an analytical toolkit for the optimization of Li-ion battery electrode manufacturing

Published: October 12 2017

The electrodes used in Li-ion batteries have a defining influence on their electrochemical performance and are typically manufactured by coating a metal foil substrate with a multicomponent slurry made up of active electrode particles and conductive

Molecular and bulk characterization of PLA and PLGA samples using multi-detector GPC and rheometry

Published: October 10 2017

Exploring the relationship between molecular characteristics and bulk rheological properties of biodegradable polymers with Malvern. Poly(lactic acid) is a biodegradable polymer derived from natural resources (corn starch), that has received

Malvern Panalytical webinar - September 2017

Published: August 31 2017

Rheology of Soft Matter – Gels and Soft Glass Transition Measurement type: Rheology and viscosity Date: September 14 2017 - September 14 2017 Time: 15:30 - 16:30 (GMT) GMT   Click Here to Register Now  

Understanding Yield Stress Measurements

Published: August 23 2017

The yield stress characteristic is a property associated with numerous types of complex fluids - whereby the material does not flow unless the applied stress exceeds a certain value. This is evident in everyday tasks such as squeezing toothpaste

Understanding the true cost of projects

Published: August 23 2017

Choosing the right approach for implementing on-line particle sizing As manufacturers turn to on-line particle size analysis, the issue of how to ensure sucessful project implementation becomes relevant. This white paper examines the economic

The impact of electrode particle size and shape on battery slurry viscosity

Published: August 23 2017

Using Morphologi G3 to monitor and control the electrode particle characteristics and viscosity of battery slurries Batteries are ubiquitous in modern life and our reliance on them has never been greater.  Therefore, ensuring optimum

Reviewing a Decade of Online Particle Sizing

Published: August 23 2017

Zementwerk Berlin GmbH & Co KG (Berlin, Germany) has been using Insitec on-line laser diffraction particle sizing (Malvern Instruments) systems to optimize cement production for more than a decade. This collaborative article reviews the

Polymer Nanoparticle Characterization Using Dynamic Light Scattering

Published: August 23 2017

Polymer nanoparticles are being used as drug delivery systems. This applications discusses the influence of temperature on the size of polymer nanoparticles using dynamic light scattering. Read more

Laser-diffraction particle sizing pays dividends for wet-process monitoring

Published: August 23 2017

Sophisticated mathematics extend the range of concentrations over which measurement is feasible In this article we take a look at how, from the starting point of an appropriate wet sensor, laser diffraction systems can be engineered to deliver

Dynamic light scattering - common terms defined

Published: August 23 2017

There are many sources of information that give a mathematical description of the terms used in light scattering. This paper gives a descriptive definition of these terms, with notes on their use in the context of Dynamic Light Scattering. Read

Differential scanning calorimetry as a diagnostic tool for cancer patients

Published: August 23 2017

Blood serum is a source of cancer biomarkers. Tumor development is accompanied by metabolic malfunction that may result in altered serum composition: proteins that are up/downregulated and low molecular weight metabolites undergoing changes in

Upcoming July Webinars from Malvern

Published: July 4 2017

Viscosizer TD - protein stability characterization platform Measurement type: Protein aggregation Date: July 11, 2017 - July 11 2017 Time: 16:30 - 17:30 (GMT) GMT Event type: Webinar - Live Language: English   Click

With high-quality powder diffraction data you can do much more than phase analysis…

Published: June 29 2017

The understanding of a crystal structure is a key component in the characterization of a new compound and a first step towards tailoring of its properties. Traditionally crystal structures are solved using single-crystal X-ray diffraction. Thanks to

Using Taylor Dispersion Analysis to determine oligomeric state of insulin

Published: June 27 2017

Taylor dispersion analysis is an emerging biophysical characterization technique that offers unique benefits in the early stages of biopharmaceutical development – providing answers that established techniques cannot effectively handle. Read

The power of multi-detector SEC in the analysis of antibodies

Published: June 27 2017

How OMNISEC can measure antibody absolute MW independent of size and structural changes This application note will describe the analysis of three antibody samples using column calibration and multi-detector SEC. Comparisons will be made between

Setting a benchmark: Using rheology to define the performance of personal care products

Published: June 27 2017

Products, quality is often defined by a range of functional and sensory attributes, some of which may be easily measured - such as color - and others which may not. Visual or textural appearance and ease of application exemplify properties in this

GPC/SEC analysis of polymer branching

Published: June 27 2017

Using triple detection GPC/SEC to understand branching in polymers This Application Note describes the triple detection GPC/SEC analysis of a variety of branched and linear PVP samples.  Branching can have a marked effect on the final

Concentration limits for zeta potential measurements in the Zetasizer Nano

Published: June 27 2017

Explains the concentration limits for successful zeta potential measurements to be made. A case study is used to illustrate the limits of concentration and describes what happens to the quality of data if the sample concentration is inappropriate.

Upcoming June Webinars from Malvern

Published: June 6 2017

Revealing the secrets of nanodisc architecture using multi-detection GPC/SEC Measurement type: Particle size Date: June 27 2017 - June 27 2017 Time: 10:30 - 11:30 -  (GMT-05:00) Eastern [US &

Top tips for avoiding particle sizing failures with your laser diffraction method

Published: May 23 2017

Particle size defines the performance of a wide range of different products, including cement, paints, inks, metal powders, cosmetics, foods and drinks. Measuring relevant particle size data is therefore essential in many industries, with laser

Particle size analysis of cement using the technique of laser diffraction

Published: May 23 2017

The critical strength and curing properties of cement are dependent on the particle size distribution of the cement components. This note describes how laser diffraction can be used as a routine method for cement particle size analysis.  

Food Safety and Quality: Sizing Up Particles

Published: May 23 2017

Particle size analysis is important in many industries. Knowledge of particle size is important in the food industry because it affects the production and handling of ingredients and the formulation, processing, and quality control of food and

Biophysical application of calorimetric methods to protein misfolding and aggregation examinations

Published: May 23 2017

The last two decades have seen important advances in our knowledge on protein folding and the stability of globular proteins, as a result of extensive studies using various biophysical approaches and theories. Calorimetry, particularly differential

Analytical characterisation of mouthfeel in chocolate

Published: May 23 2017

The particle size and rheology of the chocolate are critical factors in determing and predicting mouthfeel Chocolate is an affordable yet luxurious treat with mature markets in Europe and North America and developing markets around the world.

Using laser diffraction to measure particle size and distribution of metal powders

Published: May 8 2017

How laser diffraction fulfils the metal powder industry’s requirements for accurate particle size information Powder metallurgy, the production of a solid object from a fine metal powder, is a versatile method for creating a wide range of

Top 10 Factors to Consider When Selecting a Dynamic Light Scattering (DLS) Instrument

Published: May 8 2017

If you are considering the purchase of a dynamic light scattering system, take note of these factors as you go through the selection process. Written specifications are not necessarily a guide to system performance, and can be misleading. Click

How to use GPC/SEC for compositional analysis

Published: May 8 2017

Determining the relative concentration of two components in a polymer sample In this Application Note, one copolymer and one polymer mixture, both comprised of polystyrene (PS) and poly(methyl methacrylate) (PMMA), will be analyzed using GPC/SEC

GPC/SEC Analysis of Polymer Degradation

Published: May 8 2017

This Application Note describes the use of GPC/SEC to study the degradation of polymers from recycling and processing.  Understanding and/or minimizing these effects can greatly increase profit margins for polymer manufacturers.  

Assessing fuel filter efficiency using online laser diffraction

Published: May 8 2017

Meeting requirements for ISO16332: Standard method for evaluating fuel/water separation efficiency in diesel engines International standard ISO16332 Diesel engines — Fuel filters — Method for evaluating fuel/water separation

May Webinars from Malvern

Published: April 26 2017

An exercise in comparability: Using multi-detection SEC to evaluate the biosimilarity of monoclonal antibody biotherapeutic products A successful biosimilar program has comparative analytical data at its foundation. As part of the analytical

Malvern Webinar: Rheometer or Viscometer? Which one do I need and what is the difference?

Published: April 5 2017

A viscometer, as the name implies, is an instrument used to measure the viscosity of a fluid. Viscometers come in different shapes and sizes, and range from simple inexpensive flow cups to more expensive rotational instruments. But what makes a

The new MicroCal PEAQ-DSC Automated system

Published: March 20 2017

Eight reasons to upgrade from the MicroCal VP-Capillary DSC system   Differential scanning calorimetry (DSC) is an established biophysical tool for the characterization of protein stability . A protein's stability is a critical

Processing non-Newtonian products: Determining the pressure drop for a power law fluid along a straight circular pipe

Published: March 20 2017

This application note shows how to predict the pressure requirements for a non-Newtonian liquid to flow through a straight circular pipe.   Click here to read more.

Multi-detector GPC/SEC analysis of polysaccharides using OMNISEC

Published: March 20 2017

How moving to multi-detector GPC can give greater insight than conventional measurements. This application note will describe the analysis of three polysaccharide samples using advanced detection. Comparisons will be made between the three

How switching mobile phases can improve your OMNISEC results

Published: March 20 2017

Analysis of ester- and acid-capped PLGA samples in mobile phases of DCM and THF   In this Application Note two PLGA samples, one acid-capped and one ester-capped, will be studied in two different sets of GPC/SEC analysis conditions. The

Exploring the impact of particle characteristics on suspension rheology

Published: March 20 2017

How particle size, shape and zeta potential influence suspension rheology This white paper examines the impact of particle properties on suspension viscosity, and more broadly on rheological behavior. It looks in some detail at how particle size

Characterization of biopharmaceutical stability with Differential Scanning Calorimetry

Published: March 20 2017

Biosimilarity and batch-to-batch comparability DSC is an established analytical tool used for higher order structure (HOS) comparability studies of biopharmaceuticals, and for HOS analysis during development of biosimilars. Comparison of DSC

Upcoming March Webinars from Malvern

Published: March 6 2017

Differential Scanning Calorimetry: Robust and powerful physical characterization of therapeutic protein products Learn about the value that DSC and the assessment of thermal stability bring throughout the development of a biological drug product

Malvern launches MicroCal PEAQ-DSC

Published: February 22 2017

Water and detergent (Contrad 90) used as standard   The new MicroCal PEAQ-DSC microcalorimeter from Malvern Instruments resets the performance standard for characterizing protein and biomolecule stability.  This latest innovation

Upcoming February Webinars from Malvern

Published: February 9 2017

You can register to receive the recorded version of the webinar within a few days after the event.   Particle tracking analysis (PTA) method (ISO19430) – What it means for nanoparticle measurements This webinar will introduce

Nanobubble Applications and Characterization by Nanoparticle Tracking Analysis

Published: February 2 2017

Review of ultra-fine bubble (nanobubble) applications and characterization examples   The generation, measurement, and applied technologies of so-called nanobubbles or ultra-fine bubbles, with diameter ranging from tens to hundreds of

How investing in Malvern Instruments helped KBI Biopharma find a clear commercial advantage

Published: February 2 2017

Dr. Amber Fradkin, KBI Biopharma About KBI Biopharma Dr. Amber Fradkin manages the Particle Characterization Core Facility at KBI Biopharma in Boulder, Colorado. KBI is a biopharmaceutical contract development and manufacturing organization

Gold Nanoparticle Applications and Characterization by Nanoparticle Tracking Analysis

Published: February 2 2017

Review of nanoparticle size and concentration analysis in gold colloid applications   Gold nanoparticles are one of the most popular and extensively researched type of nanoparticle.  Many characterization techniques exist that

Comparing metal powders from different atomization processes using automated image analysis

Published: February 2 2017

Image analysis is an ideal tool for characterizing the size and shape distributions of atomized metal powders   Manufacturing metal parts by Metal Injection Molding  (MIM) is expanding rapidly. The shape and size of metal powders

Upcoming January Webinars from Malvern

Published: January 10 2017

OMNISEC for Protein characterization Size Exclusion Chromatography (SEC), is a very popular analytical technique for studying protein molecular weight, oligomeric state, aggregation, and conjugation. Malvern offers a range of multi-detector SEC

Using the Zetasizer Nano to optimize formulation stability

Published: December 23 2016

Formulation development is a critical activity for many industries, from pharmaceuticals, to paints and coatings. Indeed, it is estimated that in the UK alone, sales of formulated products amount to some £180 billion per year1. This means that

Using squeeze flow to extend rheological measurements for concentrated suspensions

Published: December 23 2016

Making shear rheological measurements on samples with a high solids fraction can present difficulties on a rotational rheometer, since the sample can be prone to fracture even at low-medium shear rates. It is possible to extend the measurement range

Using laser diffraction to characterize casein micelles and fat globules in milk

Published: December 23 2016

To improve its shelf-life, milk undergoes a homogenization process. This process produces fat globules of a uniform, small size.  During the homogenization process the size range of the fat globules is reduced from 0.1-15 ?m in unprocessed

Time to harness the true power of rheology

Published: December 23 2016

Upgrading from a viscometer to a modern rotational rheometer brings access to a range of test methods that can be applied to accelerate and enhance the formulation of personal care products

Synergy of Complementary Nanomaterial Characterization Techniques: NTA+DLS

Published: December 23 2016

Examples of complementary analytical techniques providing a more thorough understanding of nanomaterial systems

Key considerations when purchasing an advanced GPC/SEC system

Published: December 23 2016

Investing in a new GPC/SEC system is a big decision with many factors to consider. This white paper lists the key items that you should think about when buying a new system and discusses the reasons for their importance.  Finally, it discusses

Introducing Morphologically-Directed Raman Spectroscopy

Published: December 23 2016

A powerful tool for the detection of counterfeit drugs Drug formulation, an integral step in the regulated pharmaceutical industry, involves the careful blending and processing of precisely specified and measured components to create a final

Malvern Webinars - December 2016

Published: December 5 2016

Optimizing GPC/SEC measurements by combining high-performance columns and powerful advanced detectors   Measurement type: Molecular weight   Date: December 6 2016   Time: 10:30 - 11:30 Eastern US

Malvern Webinars - November 2016

Published: November 2 2016

The importance of powder quality in powder bed Additive Manufacturing processes   Measurement type: Particle size, Particle shape, Powder flow Date: November 3 2016 Time: 15:30 - 16:30  GMT  Event type: 

Using rheology to enhance formulation

Published: October 26 2016

Viscometers are used routinely to characterise food and drink roducts and offer simple, straightforward measurement for QC. They are also applied in formulation, but here rheology has far more to offer than simple viscosity measurements. Switching

Investigating the effects of excipients on the earliest stages of aggregation - Aggregation inhibition by arginine

Published: October 26 2016

Use of static and dynamic light scattering to characterize the stability of lysozyme in the presence and absence of arginine. SLS is used to assess aggregation temperature, while DLS is used to measure the various particle sizes present in the two

Five compelling reasons to replace sieve analysis with laser diffraction

Published: October 26 2016

Switching from sieve analysis to laser diffraction within manufacturing has multiple immediate benefits, the most important of which: time- and cost-savings, better and simpler characterization, better product quality and easier maintenance, are all

Exploring the Value of GPC/SEC in Polysaccharide Characterization

Published: October 26 2016

A defining feature of polysaccharides, which are used widely as food additives and for certain medical applications, is that they are naturally occurring and consequently prone to inherent variability. In this article, we discuss how advanced gel

Evaluating aggregation behaviour of liposome-protein complexes using NTA

Published: October 26 2016

Aggregation of both biological and synthetic materials is a source of serious concern, posing problems at various stages of the discovery and formulation processes. Liposomes have been used in drug discovery and drug delivery for some time, and the

Adeno-Associated Virus titer and aggregation characterization

Published: October 26 2016

In this application note, we describe a novel method to rapidly measure the size and concentration of Adeno-Associated Virus (AAV), utilizing the Nanoparticle Tracking Analysis (NTA) technique and a gold labelling method.  By labelling AAV

What Is Differential Scanning Calorimetry (DSC)?

Published: September 29 2016

Malvern Instruments MicroCal DSC team introduce what Differential Scanning Calorimetry (DSC) is and why it is the gold standard in characterizing the stability of a protein or other biomolecules. The Malvern MicroCal team details how Differential

Introduction to GPC in 30 minutes

Published: September 29 2016

Presented by GPC applications specialist Dr Kyle Williams this 30 minute introduction offers a comprehensive educational insight into the technology and its applications. Click here to watch the video

Using Rheology to Optimize the Performance of EOR Fluids

Published: September 15 2016

Although the price of crude oil has dropped significantly in the past couple of years, the longer term predictions suggest that it may settle in the region of US$50 – 70/bbl, a figure that still encourages the exploitation of existing

Sizing dairy emulsions for optimal performance

Published: September 15 2016

The particle size of fat droplets in dairy emulsions such as milk, ice cream and cream liqueurs has a defining impact on attributes such as stability, mouthfeel and whip ability, which are critical to a product’s commercial viability. In a

Particle size analysis of calcium carbonates by laser diffraction

Published: September 2 2016

Calcium Carbonate is used within a wide range of industrial products as a filler and pigment. It is also used as a source of calcium within food and pharmaceutical products. Its function is often related to its particle size and size distribution

Combined DLS/Raman provides New Molecular Insights of Complex Fluids

Published: September 1 2016

In particular, this article demonstrates the correlation between molecular changes (Raman Spectroscopy) and microstructural evolution of rheological properties (DLS, DLS-optical microrheology) for the first time for surfactant-based wormlike

Component Characterization of Cements using Morphologi G3-ID

Published: August 31 2016

Around 3 Billion tons of cement are produced every year accounting for 10-15 % of global energy usage in industry and up to 10 % of global CO2 production. The continuing growth of developing nations is creating an ever growing demand for cement,

Monitoring Microfiltration Processes for Water Treatment

Published: August 29 2016

With the increasing demands on water supplies and tighter regulations, much research is being done in to water treatment processes. Subjects of study include improving processes to allow treated water to be used in secondary applications, optimizing

Using DSC to characterize thermotropic phase transitions in lipid bilayer membranes

Published: August 27 2016

Liposomes have been widely used as model membranes and in drug delivery, as their basic properties can easily be varied to target desired properties (lipid composition, concentration, water content, media (different buffers, varying ionic strength,

A Basic Introduction to Rheology

Published: August 25 2016

Rheometry refers to the experimental technique used to determine the rheological properties of materials; rheology being defined as the study of the flow and deformation of matter which describes the interrelation between force, deformation and time

A buyer's guide to protein stability measurement platforms

Published: August 23 2016

Characterizing biopharmaceutical protein stability is critical during all phases of biopharmaceutical development, including candidate selection, preformulation screening and formulation development, process development, and manufacturing support.

Chewing the fat

Published: August 21 2016

Dr Steve Carrington of Malvern Instruments and Prof. D. J. McClements of the University of Massachusetts describe the use of rheology to measure how food changes during mastication and to compare the rheological behaviour of low fat sauces with

The Benefits of Multi-Detector SEC for Protein Analysis

Published: May 31 2016

A new article from Malvern Instruments explores how including light scattering as part of a multi-detector Size Exclusion Chromatography (SEC) system delivers accurate molecular weight (MW) measurement when assessing the activity, safety and

Malvern Webinar - March 2016

Published: March 1 2016

Applications of light scattering in pharmaceutical development Measurement type: Particle size, Molecular weight Date: March 8 2016 Time: 10:30 - 11:30 (GMT-05:00) Eastern [US & Canada] Event type: Webinar -

Malvern Webinars - January 2016

Published: January 11 2016

Rheological characterization of asphalt binders at low temperatures by using the 4-mm DSR technique. Part 1 Measurement type: Rheology and viscosity   Date: January 14 2016   Time: 10:30 -

Resolve challenges, find solutions: Join Malvern for expert help on protein interaction analysis with MicroCal PEAQ-ITC

Published: July 9 2015

At the 29th Annual Symposium of The Protein Society (22-25th July, Barcelona, Spain)  Natalia Markova,  Principal Scientist- MicroCal, Malvern Instruments, will be presenting a workshop on how to enable high resolution protein interaction