A rapid and inexpensive fluorescence method for screening conditions that affect protein thermal stability, such as protein mutations, ligand binding, and buffer formulations (like pH, salts, detergents, and other additives).

GloMelt™ dye performs very well in high detergent concentrations, unlike SYPRO® Orange

GloMelt™ dye generates a strong signal because it is optimized for detection in the SYBR® Green channel of qPCR instruments

Great for high throughput assays, low reaction volumes and low protein concentrations

GloMelt™ dye tolerates DTT very well, unlike PROTEOSTAT® PTS dye

Can be combined with ROX to get very precise replicates in qPCR systems requiring ROX reference dye