Agilent Technologies’ New Q-TOF LC/MS Offers 10 Times More Sensitivity than Previous Model, Plus 50 HZ Acquisition Rates
By: Agilent Technologies Published: June 11 2011
Instrument Raises Performance Standard for Metabolomics, Food Testing, DMPK Qual/Quan, and Protein Identification
DENVER (ASMS), June 6, 2011 – Agilent Technologies, Inc. today introduced the 6550 iFunnel quadrupole time-of-flight liquid chromatography mass spectrometry (Q-TOF LC/MS) system. It increases TOF sensitivity to low femtogram levels while delivering fast acquisition to 50 spectra/sec, up to five orders of intra-scan dynamic range, and robust performance and operation.
“Last year we debuted iFunnel technology to create the world’s most sensitive triple quadrupole system – a claim that is still very valid today,” said Ken Miller, Agilent marketing director, LC/MS. “This year we’re extending this remarkable technology to our Q-TOF. The iFunnel Q-TOF delivers the performance to characterize complex samples and find and quantify compounds at extremely low concentration levels. All this without compromising sub 1-ppm mass accuracy, high resolution or data acquisition rates.”
Superior sensitivity and speed make the 6550 iFunnel Q-TOF particularly well-suited for highly challenging qualitative and quantitative analyses in applications such as metabolomics, food-safety screening, early stage drug metabolism and pharmacokinetics, and protein identification. High-resolution TOF and Q-TOF are the systems of choice for screening unknown or unexpected chemicals.
“We are extremely pleased with the results obtained by the 6550,” said early access user Dr. Nicola Zamboni of the Institute for Molecular Systems Biology, Swiss Federal Institute of Technology Zurich. “The increase in sensitivity and resolution directly translates into 10 times more reproducibly detectable m/z features, 10 to 100 times higher ion counts, drastically wider coverage of metabolism, and yet similar coefficient of variation and outstanding mass accuracy.”
Agilent iFunnel technology was developed in conjunction with Dr. Richard Smith, inventor of the Ion Funnel, and Battelle Fellow and Chief Scientist, Pacific Northwest National Laboratories.
“Ion Funnel technology could possibly be the most significant MS development since the introduction of API,” said Dr. Smith. “It delivers a fundamental sensitivity and detection limit breakthrough, resulting in performance far exceeding the capabilities of conventional mass spectrometers.”
This breakthrough sensitivity does not come at the expense of robust operation. Careful re-engineering of the ion optics elements was required to accommodate the extremely high ion flux in this new system. This translates directly into greater reliability and uptime for labs requiring productivity and the highest levels of performance.
New MassHunter Software
The Agilent 6550 iFunnel Q-TOF is supported by new MassHunter software functionality to facilitate qualitative and quantitation analyses, as well as new Qual/Quan workflows. New Study Manager capability allows quick setup of acquisition and processing methods to boost overall system efficiency.