Sysmex XT-4000i



Designed to be reliable and efficient, the Sysmex XT-4000i offers medium to high volume laboratories an automated hematology system that can truly meet and exceed expectations. The XT-4000i provides a 6-part WBC differential, including enumerated Immature Granulocytes (IG # and %) to minimize slide reviews. The analyzer has a second fluorescent platelet method, PLT-O, on-board to help resolve platelet flags and minimize manual counts. Reticulocytes are fully automatic and require no pretreatments or testing delays. Body fluid samples, including CSF, serous fluid and spinal fluid, are analyzed. The seven (7) parameters reported include a 2-part WBC differential. The XT-4000i streamlines your workflow by providing testing for up to 100 samples per hour on whole blood, enabling rapid turnaround time.
Depth 28.3 in Main Unit including sampler:
Height 24.8 in Main Unit including sampler:
Width 20.9 in Main Unit including sampler:
Additional Specifications 27 Whole Blood Reportable Parameters:  
CBC with 6-part differential including IG% and # 
2 platelet methods on-board 
Reticulocyte panel providing RET%, RET#, IRF, and RET-He 
7 Body Fluid Reportable Parameters:  
WBC-BF TC-BF, RBC-BF, MN%, MN#, PMN%, and PMN#  
Whole Blood Linearity:  
WBC: 0 – 440.00 x 103/ΜL 
RBC: 0 – 8.00 x 106/ΜL 
PLT: 0 – 5,000 x 103/ΜL 
Body Fluid Linearity: 
WBC-BF: 0.004 – 10.000 x 103/ΜL 
TC-BF: 0.004 – 10.000 x 103/ΜL 
RBC-BF: 0.001 – 5.000 x 106/ΜL 
Whole blood mode: 100 samples/hour (max.) 
Body fluid mode: 30 samples/hour (max.) 
Sample Volumes: 
Closed mode: 150 ΜL 
Open mode: 85 ΜL 
Capillary mode: 40 ΜL


The Sysmex XT-4000i hematology analyzers utilize the power of fluorescent flow cytometry and hydrodynamic focusing technologies. Using a unique and advanced diode laser bench, Sysmex fluorescent flow cytometry provides the sensitivity needed for measuring and differentiating cell types in whole blood and body fluid samples. Fluorescent technology and hydrodynamic focusing enable the XT-4000i to consistently classify normal WBC, RBC and PLT populations from abnormal populations, thereby decreasing the number of manual interventions. XT-4000i technology provides clinically relevant and reportable parameters.  
  • Immature granulocyte count (IG%, #) with reportable, quantitative results for metamyelocytes, myelocytes and promyelocytes 
  • Reduce false positive and false negative rates 
  • Obtain result consistency by reducing tech-to-tech variation in reporting manual differentials 
  • Improve turnaround time with fewer manual differentials 
  • Platelet counts by a fluorescent optical method and by traditional impedance technology to improve accuracy of very low and very high PLT counts 
  • Obtain accurate counts when interferences are present 
  • Offers automated judgment for reporting PLT-O or PLT-I through instrument settings 
  • Retic: Fluorescent reticulocyte count to reduce manual confirmation methods and the inherent errors 
  • Eliminate common interferences to avoid manual counts 
  • RET-He: Reticulocyte hemoglobin content measures the incorporation of iron into the red cell to assist the physician with anemia evaluation and management (e.g., functional iron deficiency anemia) 
  • Provides rapid and direct analysis of an earlier stage of RBC development 
  • Is an established parameter used in KDOQI (Kidney Disease Outcome Quality Initiative) guidelines for assessing the initial iron status of patients 
  • Supports effective monitoring of costly drug protocols for cell stimulation 
  • Body Fluids: Excellent low end sensitivity with seven parameters, including a 2-part differential to eliminate the need for manual counts 
  • Provides expanded sensitivity and linearity – WBC and RBC counts reportable to three decimal places 
  • Includes a 2-Part differential 
  • Automated background check prior to analyzing a sample 


Sysmex XT-4000i Automated Hematology Analyzer

Sysmex XT-4000i Automated Hematology Analyzer

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Medical lab technologist

what is the difference between open mode and capillary mode? My lab just got sysmex 4000i and I'm impressed at the very low volume it needs for the manual mode...just ran a short sample baby cbc and retic. I'm think the volume it needed was 40...

sysmex 4000i wbc zero results

greetings!                 what is the possible cause if the result of WBC is zero? but the other parameters are good, thank you and hoping for possitive response  

Specimen handling requirements

I am looking for specimen handling requirements, particularly the storage temperature and stability on all components run on the xt4000i

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