Biotage Isolera™ Dalton


Isolera™ Dalton

Be sure you have your target compound the moment your purification is complete. Isolera™ Dalton integrates the Biotage approach to flash chromatography with true compound identification using mass detection. 
For the first time, Flash chemists can automatically collect targeted mass fractions of their compounds on a flash system. Isolera™ Dalton is nothing less than a fully-fledged mass identifier system specifically designed to plug seamlessly into the Isolera™ family. 
Provided by a company with over twenty years’ experience in Flash chromatography, Isolera Dalton represents the most advanced and innovative purification system available, designed by people who understand Flash purification and the needs of the synthetic chemist.
Isolera™ Dalton
Depth 62 cm
Height 59 cm
Width 85 cm
Power Requirements 100–240 V AC; 50–60 Hz
Peak Power 320 VA (Isolera™ Dalton Mass Detector)
Weight 77 kg
Additional Specifications Dimensions (W x H x D)  
Isolera™ Dalton Mass Detector: 
35.5 x 56 x 25 cm 
Isolera™ Dalton Nanolink: 
35.4 x 52.5 x 21 cm 
Isolera™ Dalton Mass Detector:  
32 kg 
Isolera™ Dalton Nanolink:  
10 kg 
35 kg 
Mass Analyzer:  
Miniaturized single quadrupole 
Ionization Source:  
Chip based electrospray ionization 
Detection Range:  
m/z 80–800 
Mass Accuracy:  
± m/z 0.5 in full scan in a temperature controlled environment, ±3 °C 
Mass Resolution:  
m/z 0.7 ±0.1 FWHM in full scan in a temperature controlled environment, ±3 °C 
Sampling Adjustment:  
Start-up Time:  
30 minutes* 
Vacuum Pumps:  
Fully integrated 
Control Interface:  
Isolera™ Spektra 
User Serviceable Parts:  
Spraychip® (chip based ESI source) Vac-chip™ (micro engineered atmospheric pressure interface) 
Compatible Systems:  
Isolera™ Spektra Flash Chromatography systems 
Gas Requirement:  
2–6 bar N2 
Gas Consumption:  
2.5 L/min 
Power Consumption:  
130 VA (Isolera™ Dalton Nanolink) 
CE, cTÜVus 
*Includes pump-down to vacuum


Streamlined Workflow 
Isolera Dalton brings mass detection to flash chromatography. This system identifies compounds by mass in real time during Flash separation, leading to greater confidence in purification and a significant saving in time and money. This combination of identification and purification removes complex off-line analytical steps from the workflow, vastly increasing throughput and putting the entire purification and analysis in the hands of the chemist. 
Reactor content can be injected directly to identify target masses, which then are transferred directly to the Flash method for mass targeted purification. 
Tailored Technology 
Isolera Dalton automates and takes the hard work out of the compound identification and purification, perfect for chemists whose priorities lie more towards the chemistry than small details of running the analysis. Minimal user intervention required makes it available to chemists unfamiliar with mass detection or those whose priorities lie in compound synthesis rather than analysis. 
Isolera™ Dalton Mass Detector uses a chip-based electrospray system with a miniaturized quadrupole and internal vacuum pumps, allowing the system to easily fit in a fume hood, and is capable of handling both normal and reverse-phase samples with ease.  
Intelligent Integration 
Seamless interaction between a flash system and a mass detector requires advanced technology and fine tuning. This is all taken care of by the Isolera™ Dalton Nanolink interface, an intelligent sampling device that at any given moment provides Isolera Dalton Mass Detector with the exact amount of sample required, and dynamically adjusts to the solvent effluent flow rate employed in the Flash system. 
Isolera™ Spektra software with its graphic user interface provides a straightforward controlling environment, giving easy access to the process. 
  • Compound identification by mass during purification and by direct injection 
  • Fully automated integration of Flash purification and mass detection via the Isolera™ Dalton Nanolink 
  • Automatically accommodates different flash flow rates 
  • Simple wizard-based approach to method development 
  • Compact system with miniaturized mass detector, easily fits inside a fume hood with no external pumps 


Isolera™ Dalton

Isolera™ Dalton

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