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Malvern Panalytical Viscosizer TD

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Viscosizer TD

Malvern Viscosizer TD is an automated biophysical characterization tool utilizing Taylor Dispersion Analysis and providing ultra-low volume, solution-based molecular size and stability measurement capabilities, combined with Poiseuille flow for relative viscosity assessment. Viscosizer TD offers biopharmaceutical researchers an orthogonal technique for conformational stability analysis, which is unrivaled in extending into label-free measurements in highly complex solutions, and encompasses a critical size range from small molecules through to protein-based systems.
Viscosizer TD
Attributes
Additional Specifications Molecular (particle) size:   
Taylor Dispersion Analysis using UV Area Imaging   
Relative viscosity:   
Poiseuille's law   
Sample measurement temperature range:   
4°C - 40°C(1)   
Sample storage temperature range:   
4°C - 40°C(1)   
Minimum measurement and storage temperature:   
20°C below ambient(2)   
Pressure range:   
0 - 3000mbar   
Maximum number of sample vials per run:   
50   
Wavelength:   
200nm - 325nm   
User selectable filter:   
214nm; 254nm or 280nm   
   
Autosampler unit   
   
Dimensions (W, D, H):   
480mm x 660mm x 430mm   
Weight:   
43kg   
   
Control box   
   
Dimensions (W, D, H):   
121mm x 315mm x 331mm   
Weight:   
7kg   
   
Operating environment   
   
Nominal operating voltage:   
100/240V; 50/60 Hz   
Ambient temperature range:   
16°C - 30°C

Features

  • Viscosizer TD is an easy to use system with sample storage and presentation in a temperature-controlled autosampler to ensure sample integrity   
  • Flexible and intuitive software interface provides fully automated test schedules and data analyses for walk-away operation   
  • 40 nanoliter sample volume for molecular sizing and 6 microliter sample volume for relative viscosity   
  • Total sample volume of 35 microliters required for triplicate measurements for both size and relative viscosity on one sample (15 microliter excess is recoverable)   
  • UV detection for molecular sizing allows measurements at low concentration down to microgram quantities   
  • Relative viscosity measurements with unique dual pass timing provides high resolution measurements with high reproducibility at low concentration and low viscosity   
  • Taylor Dispersion Analysis spans an unmatched molecular size range in solution, from small molecule size, peptide size and protein size, and samples with mixtures of these species   
  • Orthogonal technique for protein stability assay and protein solubility studies from candidate validation into early stage formulation development   
  • Novel technique for biopharmaceutical researchers to assess peptide stability and peptide solubility   
  • UV wavelength can be changed to optimize measurement sensitivity and molecular selectivity   
  • Using a matched sample buffer effectively renders excipients and surfactants invisible, enabling label-free characterization of target biomolecules in complex solutions   
  • Measurements are not adversely affected by the presence of a small amount of aggregates, meaning samples can be run with minimal sample preparation and without dilution or filtration
  • Photos

    Malvern Viscosizer TD

    Malvern Viscosizer TD

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    Malvern Panalytical provides materials and biophysical characterization technology and expertise.

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