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Lonza Group Ltd. Silensomes™ Human Liver Microsomes

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Silensomes™ Human Liver Microsomes

Silensomes™ are validated human pooled liver microsomes (HLM) chemically and irreversibly inactivated for one specific CYP using mechanism based inhibitors (MBI). Each Silensomes™ HLM is available as cryopreserved, ready-to-use HLMs chemically knocked-out for one specific CYP activity (1A2, 2A6, 2B6, 2C8, 2C9, 2D6, 3A4) with each showing high specificity and efficiency of their targeted CYP inhibition (>80%), and only minor impact (<20%). The thaw and go format of Silensomes™ HLM enables researchers to focus more on results and less on validating the level of CYP inhibitions.

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