Malvern Panalytical Morphologi 4


Morphologi 4

Rapid, automated particle size and particle shape analysis   
Morphologi 4 provides detailed morphological descriptions of particulate samples through static image analysis, enabling a greater understanding of both sample and process. It can equally be used as an R&D tool to investigate challenging applications and in automated QC analysis where generation of robust, user-independent results and validation are required.   
    Broad particle size range, from 0.5 Μm to over >1300 Μm, enables size measurements of a wide range of samples 
    20+ morphological parameters deliver a highly-detailed description for deeper understanding of your particulate material 
    SOP control, from sample dispersion to data analysis, provides simple and automated operation for robust, repeatable measurements 
    Automated ‘Sharp Edge’ analysis enables detection of even low contrast particles 
    Advanced manual microscope mode and ability to return to particles of interest enables an even closer examination of unexpected particles 
    High resolution microscope ensures quality particle images for optimum image analysis data 
    Integrated dry powder dispersion unit delivers reproducible sample dispersion, critical to achieving meaningful results 
    Dedicated sample presentation accessories enable measurement of a wide variety of sample types, including suspensions and filters 
    Advanced data exploration tools generate maximum sample knowledge 
    21 CFR Part 11 software option ensures regulatory compliance 
The Morphologi 4 measurement procedure can be split into four sections:  
Sample preparation  
Spatial separation of individual particles and agglomerates is critical to representative results. The integrated dry powder disperser makes preparing dry powder samples easy and reproducible. The applied dispersion energy can be precisely controlled, enabling the measurement process to be optimized for a range of material types. Dispersion is achieved without explosively shocking the particles, avoiding the damage of fragile particles whilst ensuring strongly-agglomerated materials are dispersed. Accessories that fit directly in to the Morphologi 4’s automated stage are available for preparing suspended or filtered samples.  
Image capture  
The instrument captures images of individual particles by scanning the sample underneath the microscope optics. The Morphologi 4 can illuminate the sample from below or above, whilst accurately controlling the light levels.  
Image processing  
Use of either the automated ‘Sharp Edge’ segmentation analysis or the manually-controlled thresholding enables the detection of particles and the calculation of a range of morphological properties for each. 
Results generation  
Statistically representative distributions are constructed for each parameter from the thousands of particles that have been analyzed. Advanced graphing and data classification options in the software ensure that extracting the relevant data from the measurement is straightforward, via an intuitive visual interface. Individually-stored grayscale images for each particle provide qualitative verification of the quantitative results.


Technology : Static automated imaging  
Particle size : 0.5 Μm – 1300 Μm (upper limit may be extended for some applications*)  
Particle properties measured : Size, shape, transparency, count, location  
Particle size parameters : 
Circle equivalent (CE) diameter, length, width, perimeter, area, maximum distance, sphere equivalent (SE) volume, fiber total length, fiber width 
Particle shape parameters : 
Aspect ratio, circularity, convexity, elongation, high sensitivity (HS) circularity, solidity, fiber elongation, fiber straightness 
Particle transparency parameters : Intensity mean, intensity standard deviation Integrated Sample Dispersion Unit : 
For fully automated dispersion and measurement of dry powders. Manual or SOP control of 
dispersion pressure, injection time and settling time 
Illumination : White light LED: brightfield, diascopic and episcopic; darkfield, episcopic  
Detector : 18 MP; 4912 x 3684 pixel color CCD array; pixel size 1.25 Μm x 1.25 Μm Optical system : Nikon CFI 60 brightfield / darkfield system  
Lens (and particle size range) : 
2.5x: 8.5 µm – 1300 µm (nominal)  
5x: 4.5 µm – 520 µm (nominal)  
10x: 2.5 µm – 260 µm (nominal)  
20x: 1.5 µm – 130 µm (nominal)  
50x: 0.5 µm – 50 µm (nominal) 
Weight and dimensions: 
Dimensions (W, D, H) : 
810 mm (W) x 520 mm (D) x 685 mm (H) 
with carry handles: 1100mm (W) x 520mm (D) x 685mm (H) 
Weight : 76 kg (84kg including carry handles)  
Power : 100-240 V ac 50/60 Hz (<100W load)  
Notes : * Sample and substrate dependent


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