Thermo Scientific LCQ Fleet Ion Trap

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LCQ Fleet Ion Trap

The cost-effective Thermo Scientific* LCQ Fleet Ion Trap Mass Spectrometer delivers rich information for routine analysis of complex samples while providing excellent full-scan sensitivity, ruggedness and reliability.

From the inventors of benchtop LC/MS ion trap technology, the LCQ Fleet is part of the industry-leading portfolio of Thermo Scientific ion trap mass spectrometers known for their robustness and reliability. The LCQ Fleet delivers rich information for routine analysis of complex samples and integrates seamlessly with HPLC systems under a single-point of control. Automated features enable all users, from novice to expert, to easily analyze and interpret data. Application-specific software aids data processing and compound identification, assisting users in generating meaningful information.

With the Accela™ High Speed LC System, the LCQ Fleet is the perfect tool for high throughout applications.
LCQ Fleet Ion Trap
Attributes
Mass Range 100 to 4000 m/z
Mass Spectrometer Type Ion-Trap Mass Analyzer
Depth 59 cm
Height 56 cm
Width 79 cm
Power Requirements 120 or 230 VAC single phase
Weight 120 kg
Additional Specifications Hardware Features
Ion Max-S API Source
- Enhanced sensitivity and ruggedness
- Sweep Gas™ reduces chemical noise
- 60° interchangeable ion probe orientation
- Removable metal ion capillary tube provides vent-free maintenance

Options
- ESI source compatible with liquid flow rates of <1 µL/min to 1 mL/min, without splitting
- APCI source compatible with liquid flow rates of 50 µL/min to 2 mL/min, without splitting
- APCI/APPI source compatible with liquid flow rates of 50 µL/min to 2 mL/min, without splitting
- Metal needle option for high- and low-flow analyses
- HESI source compatible with liquid flow rates of <1 µL/min to 1 mL/min, without
splitting
- Nanospray II source supports static packed tip and dynamic nanospray experiments,
compatible with liquid flow rates of 50 nL/min* to 2 µL/min
* Lower limit is dependent on gauge of needle used

Transfer Ion Optics
- Advanced multipole ion guides
- High stability and ion transmission efficiency

Vacuum System
- Differentially-pumped vacuum system to 10-5 Torr
- Split-flow turbomolecular pump controls vacuum in three regions
- High-vacuum machined aluminum analyzer chamber

Detection System
- Patented conversion dynode detector
- Off-axis continuous dynode electron multipliers with extended dynamic range
- Digital electronic noise discrimination
- High-efficiency radial ion ejection

Integrated Divert Valve
- Fully-automated data system control enables user to divert to waste the solvent front, gradient end point and any other portion of the HPLC run
- User-definable default state of the valve, either “to waste” or “to source”

Integrated Syringe Pump
- Syringe Pump allows automated infusion under data system control

System Specifications
MS/MS Sensitivity
Electrospray Ionization (ESI)- A loop injection of 2 µL of a 1 pg/µL solution of reserpine (2 picograms, 3.28 picomoles total sample) at a flow of 400 µL/min of 50% isopropyl alcohol/50% water will produce a minimum signal-to-noise ratio of 100:1, for the transition of the isolated protonated molecular ion at m/z 609 to the largest two product ions, 397 and 448, when the mass spectrometer is operated at unit resolution in the full-scan MS/MS mode, scanning the product ion spectrum from m/z 165 – 615.

Atmospheric Pressure Chemical
Ionization (APCI)– A loop injection of 2 µL of a 1 pg/µL solution of reserpine (2 picograms, 3.28 picomoles total sample) at a flow of 400 µL/min of 50% isopropyl alcohol/50% water will produce a minimum signal-to-noise ratio of 100:1, for the transition of the isolated protonated molecular ion at m/z 609 to the largest two product ions, 397 and 448, when the mass spectrometer is operated at unit resolution in the full-scan MS/MS mode, scanning the product ion spectrum from m/z 165 – 615.

Installation Requirements
Power
- One 230 Vac ±10.0%, 15 Amps, 50/60 Hz, single phase, with earth ground dedicated to the instrument
- 120 or 230 Vac single phase, with earth ground for the data system

Gas
- One high-purity (99% pure, flow rate 15 L/min) nitrogen gas supply for the API source
- One ultra high-purity helium gas supply (99.998% pure) with less than 1 ppm each of water, oxygen, and total hydrocarbons for the mass analyzer

Environment
- System averages 2300 W (8000 Btu/h) output when considering air conditioning needs
- Operating environment must be 15-27 °C (59-80 °F) and relative humidity must be 40-80% with no condensation
- Optimum operating temperature is 18-21 °C (65-70 °F)

Dimensions/Weight
- Roughing pumps: 38.6 kg

Performance Specifications
Mass Range
- m/z 15 – 200
- m/z 50 – 2000
- m/z 100 – 4000

Resolution
- Down to 0.3 FWHM (full width half maximum) with Zoom Scan

Scan Power
- MSn, for n = 1 through 10
- Contact Closure
- Start In/Out
- Start Out is programmable

Analog Inputs
- One (1) analog Input (0-1 V)
- One (1) analog Input (0-10 V)

Features

Exceptional Analytical Value
  • Proven performance for compound identification in complex matrices
  • Easy to use single-point LC-MSn
  • Automatic Gain Control (AGC*) ensures optimum charge population
  • Normalized Collision Energy* for library-searchable spectra
  • Fast polarity switching provides comprehensive information
  • Rugged Ion Max* source

Recommended for:
  • Natural Product Analysis
  • Impurity Analysis
  • General Analytical Chemistry

Compatible with: Learn more about accelerating analysis with the perfect partner for mass spectrometry instruments, Accela* High Speed LC System—an HPLC and U-HPLC in one system.

Intelligent Analysis

Stable and easy-to-use Xcalibur™ software provides automated LC-MS/MS system control and data acquisition for complex sample analysis.
  • Data Dependent™ Acquisition – triggers acquisition of MSn spectra only when a compound of interest is detected
  • Dynamic Exclusion™ – allows acquisition of MSn spectra from lower intensity ion species
  • Automatic Gain Control™ (AGC) – ensures that the ion trap is always filled with the optimum number of ions for any scan type
  • WideBand Activation™ – fragments the water loss ion within an MS/MS spectrum, generating more structurally informative spectra
  • Normalized Collision Energy™ – compensates for the mass-dependent energy deposition in ion trap MS/MS experiments, providing reproducible data from instrument to instrument
  • Pulsed-Q Dissociation (PQD)™ – enables trapping of low mass fragment ions

Automated features enable all users, from novice to expert, to easily analyze and interpret sample analysis data. Application-specific software aids data processing and compound identification.
  • Mass Frontier™ – spectral interpretation and classification software to identify unknowns
  • MetWorks™ – automated metabolite identification using spectral trees
  • BioWorks™ – protein identification and quantitation featuring SEQUEST™
  • ToxID – data processing for general unknown screening
  • SIEVE™ – automated label-free differential expression of proteomics and metabolomics data

Photos

LCQ Fleet Ion Trap

LCQ Fleet Ion Trap

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Questions and Answers

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vacuum

My LCQ Fleet seems unable to go below 2E-5 Torr, and has stabilised around 2.15E-5.Anyone can point out what are the main causes of such failure?

thermo LCQ fleet_sensitivity issue..

I am unable to get sensitivity on the instrument, however Reserpine have shown the acceptable sensitivity for the system. Help!!

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