Is Water Safe To Inject In Gas Chromatography?
This is a frequently asked question based on a long history of water injections in gas chromatography. As time goes by, the rules often change.
In the first GC columns, gas chromatography phases were simply coated onto the column. This was mostly the case with packed columns, but also the same with the very first capillary columns. Injecting water onto these phases dissolved the phase and caused the phase to elute from the columns.
Over time, the capillary columns were bonded instead of coated. This chemical bonding made them stable to water injections, as well as solvent rinsing.
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