Phenomenex Adds Two Phases to Lux® 10 µm Chiral Bulk Media Line for Preparative Chromatography

Phenomenex, Inc., a global leader in the research and manufacture of advanced technologies for the separation sciences, announces the extension of its successful Lux chiral bulk media line to meet the needs of preparative chromatography applications. Lux Cellulose-3 and Cellulose-4, unique and complementary chiral stationary phases, are now available in a 10 µm particle size for preparative and batch chromatography applications. These two new phases join the existing purification media options of Cellulose-1 and Cellulose-2, providing a dependable, high-resolution screening set with a wide range of selectivity.

The new 10 µm particles are specifically designed for batch chromatography, and columns packed with these particles deliver increased efficiencies over 20 µm particles, enabling the use of shorter columns. This saves both time and money by reducing solvent consumption. The Phenomenex Lux 20 µm particles are still a good choice for customers using simulated moving bed (SMB) technology.

The four 10 µm Lux Cellulose chiral phases benefit from Phenomenex’s unique manufacturing process and silica coating technology. Lux Cellulose-1 uses cellulose tris (3, 5-dimethylphenylcarbamate) as the chiral selector. Lux Cellulose-2 provides a second chiral selector, cellulose tris (3-chloro-4-methylphenylcarbamate) providing a unique chlorinated stationary phase with chiral recognition abilities that complement the Lux family of columns. Lux Cellulose-3 utilizes Cellulose tris (4-methylbenzoate) as the chiral selector, a variant cellulose ester derivative that offers unique chiral recognition abilities to provide enantioseparation when other phases fail. Lux Cellulose-4 incorporates Cellulose tris (4-chloro-3-methylphenylcarbamate) as the chiral selector – a chlorinated cellulose phenylcarbamate derivative that offers unique chiral recognition abilities.

“The successful resolution of chiral compounds requires more than one stationary phase and the more phases you have to choose from, the better your chances of resolving enantiomers,” explains Marc Jacob, Ph.D., product manager for Phenomenex. “Our entire line of Lux media have been very successful in resolving hundreds of enantiomers and we are pleased to expand our product offering to meet the demanding needs of preparative chromatography applications.”

Phenomenex also offers several free tools for chiral chromatography. On the Phenomenex website, users are able to use the online chiral application search to quickly and easily search over 2,000 chiral applications by drawing the compound structure or by searching the application name. Phenomenex also offers free chiral screening services from PhenoLogix, a full-service analytical support laboratory that specializes in chiral method development and small-scale purifications. This group has a greater than 90 percent success rate in finding a chiral column that will separate the toughest chiral compounds.