New TripleTOF® 6600 System with SWATH™ Acquisition 2.0 Captures Every Detectable Protein and Peptide in Every Run for Deep Insights into the Proteome

AB SCIEX, a global leader in life science analytical technologies, today introduced the TripleTOF 6600 system with SWATH Acquisition 2.0 – the company’s revolutionary solution for quantitative proteomics. This high-resolution, accurate-mass system, combined with the new SWATH Acquisition 2.0, brings new power to proteomic data challenges for advanced biomarker discovery and systems biology. As the emphasis in proteomics research shifts from cataloguing to comprehensive quantitation, the AB SCIEX solution is uniquely positioned, enabling the quantification of thousands of proteins across large sample sets with a level of data completeness and quantitative accuracy and precision that have only been achievable by “gold-standard,” targeted MRM in the past.

“The TripleTOF 6600 system with SWATH 2.0 truly transforms proteomics research by providing an advanced level of data completeness and quantitative accuracy” said Rainer Blair, President of AB Sciex, “The new platform empowers researchers to gain greater insights into biomarkers and disease pathways, which will lead to earlier disease detection and, some day, personalized therapies.”

AB SCIEX SWATH Acquisition incorporates a data-independent acquisition strategy and has re-invigorated the proteomics community’s interest in comprehensive data by fragmenting every detectable peptide in the sample in order to acquire quantitative MS/MS data. This approach has been shown to increase the capacity of targeted proteomics experiments by over 30-fold and reduce study time by as much as 90 percent. Now, with the increased dynamic range of the TripleTOF 6600 System, researchers can more deeply interrogate complex samples. Combined with innovative variable window acquisition and the SWATH 2.0 processing software, a significant improvement in quantitative results has been realized