Waters Corporation introduced the Waters® Xevo® G2-XS mass spectrometer, a new high performance benchtop quadrupole time-of-flight (QTof) mass spectrometer, at the 62nd conference of the American Society of Mass Spectrometry (ASMS). Featuring the new XS Collision Cell, the Xevo G2-XS QTof stands alone among its peers in offering uncompromised analytical sensitivity and selectivity in a benchtop QTof mass spectrometer.
Shipment of Xevo G2-XS QTof to customer laboratories is expected to begin at the end of the second quarter with MassLynx® software and in the fourth quarter under the UNIFI® Scientific Information System. “The technology embodied in the Xevo G2-XS benefits laboratory analysis in a number of ways. Most importantly, laboratories now have a dependable option for performing qualitative and quantitative experiments for both known and unknown analytes with a benchtop QTof instrument,” said Brian Smith, Vice President – Mass Spectrometry Operations, Waters Division.
The Xevo G2-XS QTof mass spectrometer combines the new XS Collision Cell with the proven, signature technologies of Tof-MRM, StepWaveTM and QuanTofTM to deliver optimum levels of robust sensitivity and selectivity, resulting in the detection of more low-level compounds than ever before.
For targeted quantitative experiments, Tof-MRM mode delivers a 10-fold improvement in signal-to-noise when compared to full scan mode, resulting in limits of detection and quantification that completely redefine expectations for a benchtop high resolution mass spectrometer.
Another feature of the Xevo G2-XS QTof is the Waters MSE technology, a patented method of data acquisition that comprehensively catalogs complex samples in a single analysis. One who uses it routinely for metabolite profiling is Jessica Prenni, Ph.D., a Waters Centers of Innovation Program honoree and Director of the Proteomics and Metabolomics Facility at Colorado State University. “My team and I agree MSE technology is invaluable for non-targeted metabolite profiling. We’ve developed a new data analysis workflow that allows us to de-convolute the MSE data and recreate spectra for the metabolites that we’re seeing at both low-collision energy and high-collision energy. These spectra are then used to facilitate metabolite annotation. The ability to acquire MSE is really something that sets the Waters instruments apart,” says Dr. Prenni.
Designed for use with Waters MassLynx mass spectrometry software and UNIFI Scientific Information System, the Xevo G2-XS QTof is compatible with a variety of inlet technologies including standard flow UltraPerformance LC® (ACQUITY UPLC® H-Class and I-Class), micro/nano flow Ultra Performance LC (ACQUITY UPLC M-Class), and convergence chromatography (ACQUITY UPC2®), as well as gas chromatography via an Atmospheric Pressure GC interface.