Waters Introduces Xevo TQ-XS, the Most Sensitive Benchtop Mass Spectrometer Available

Waters Corporation today introduced the new Xevo® TQ-XS mass spectrometer, the most sensitive benchtop tandem quadrupole instrument available. Enabled by the newly designed StepWaveTM XS ion guide, this mass spectrometry system features a unique combination of ion optics, detection and ionization technologies resulting in levels of sensitivity not previously seen. The Xevo TQ-XS is expected to be available for shipment in June 2016 and will be on public display for the first time at MSSJ in Osaka, Japan, May 18 - 20, and at ASMS in San Antonio, TX, June 5 – 9.

“UPLC-MS quantitative studies are more important than ever and factor into just about every decision made by scientists. Today’s customers need to carry out reproducible quantitative studies and reach lower limits of quantification with an instrument that is accessible to all users. With this new mass spectrometer, our product designers pioneered some ingenious electronic and mechanical advances,” said Gary Harland, Senior Director MS Product Management. “With a thorough understanding of the instrument physics, they’ve engineered an analytical tool that leads to new levels of reliability, reproducibility, and performance never before seen in quantitative mass spectrometry analysis.”

These new levels of performance have been achieved through a number of technological advances. The new StepWave XS ion guide removes neutral species and transmits ions in a more focused beam to the detector by incorporating segmented quadrupole transfer optics in the second stage. The result is a 2x to 10x increase in signal/noise over its StepWave predecessor, and it delivers excellent robustness over thousands of injections. The refined design allows the system to quantify challenging compounds at trace levels - even if they are labile or show poor transmission efficiency.

Customer experience has been improved through the introduction of the new tool-free atmospheric pressure ionization probes. These allow scientists to perform routine maintenance in less than two minutes meaning greater operator-to operator reproducibility and more time analyzing samples.

The Xevo TQ-XS also incorporates the XDR Detector. First introduced on the Xevo TQ-S micro, it is a photomultiplier detection system capable of quantifying sample compounds across a concentration range of six orders of magnitude. Scientists no longer need to dilute and re-inject samples in order to stay within the limited dynamic range of the instrument they have been using.

UniSprayTM, a novel, proprietary ionization source available on the Xevo TQ-XS, enables ionization of a wider range of analytes in a single chromatographic run. The result is an increased response across a wide range of compound polarities for a broader range of compounds accompanied by a boost in signal/noise, making it possible to consolidate several analytical methods into one, or eliminate the need to change ionization sources between analyses, saving time and increasing laboratory efficiency.

The Xevo TQ-XS system joins a portfolio of Xevo mass spectrometers including; the Xevo TQD, the Xevo TQ-S micro and the Xevo G2-XS QTof. Xevo mass spectrometers are characterized by their universal ion source architecture: interchangeable ion sources that can be fitted to, or removed from, the face of the mass spectrometer in minutes, without the need to vent the system. This has changed the way analytical chemists with little previous mass spectrometry experience working in high-throughput labs can use the instrumentation at maximum performance.