The dorsal root ganglion (DRG) contains cell bodies of primary sensory neurons and is located at the posterior root of each spinal nerve. Neurons of the DRG are considered pseudounipolar since they have two axons instead of a single axon and dendrite. One of these axons extends towards the spinal cord, while the other extends towards the skin or muscle.
Since primary sensory neurons are responsible for transmitting information from the periphery to the spinal cord, they are involved in many different neural research applications, including:
- Neurotoxicity and drug screening
- Neurodegenerative disease
- Neuropathic pain
- Receptor signaling
- Tissue engineering
- Gene expression
- Intracellular transport
- Metabolic pathway
With years of experience in primary cell isolation, Lonza offers only the highest quality neural cells for your research. Lonza’s ready-to- use cryopreserved neurons exhibit the same growth cone, axon growth, morphology, and neurochemistry when compared to freshly isolated cells.
In addition, Lonza offers Primary Neuron Growth Media (PNGM™) specifically developed for culturing embryonic primary rat and mouse neurons. Researchers culturing DRG neurons can expect lot-to- lot consistency, maximal cell growth and performance when using this optimized neural culture media.
Lonza’s PNGM™ Primary Neuron Growth Media BulletKit:
- Ensures long-term neuron survival and growth
- Maintains pure cell populations
- Eliminates the need for astrocyte feeder layers
- Is serum free