GEA Pharma Systems - Collette High Shear Mixer Granulators
GEA Pharma Systems - Collette™ has supplied mixer and granulator systems to various industries for more than a century.
Collette's plant and process expertise is based on experience and R&D. With more than 1000 plants installed around the world and literally thousands of tests performed, it has established a solid base of expertise related to the needs of the pharmaceutical manufacturing industry.
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Features of Collette High Shear Mixer Granulators
Plant design: Through the wall design offers the best option in terms of cleanliness, maintenance and explosion protection. Moveable Head – The UltimaGral™ can be equipped with a ‘Movable Head’ to enhance flexibility. This feature allows operators to lower the closed bowl to enable better accessibility and easy loading. Binder solution addition - In a wet granulation process, binder addition is one of the critical phases determining product quality. A range of binder addition systems is available to give the optimum binder liquid droplet size. Process Control & Monitoring: A range of control systems for maximum level of flexibility and functionality for process visualisation, automation and data recording PAT Integration – Combining process monitoring using online analysers, together with solid process engineering principles and advanced process modelling techniques will enable processes to be actively controlled in order to compensate for minor input variations (eg. raw materials) so that the specifications for the final product will be closer to the ideal target.
Cleanability & Maintenance:
Concealed services * CIP and WIP
Containment: * Complete contained processing * For loading and unloading Buck® high containment split-valve technology * For toxic compounds, isolator boxes can be integrated * Product sampling Continuous Improvement for Safety: EC type approved for pressure shock resistant integrated systems and 16-bar pressure shock resistant high shear granulators
From R&D to large scale production Collette™ is the perfect partner for the development of a granulation process from formulation up to full-scale production. With capacities from 10 to 1200 liter, the UltimaGral™ range can cover all requirements, from development over clinical batch production for scale-up trials to large scale production for marketed products.
General Specifications
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Additional Specifications
Collette UltimaGral™ product range:
Development:
UltimaGral™ 10/25, batches 1-9kg
Pilot Scale:
UltimaGral™ 75/150, batches 10-50kg
Production Scale:
UltimaGral™ 300 to 1500, batches 50-550kg