Malvern Panalytical - SEC-MALS 20
The Viscotek SEC-MALS 20 is the most advanced multi-angle light scattering detector, for GPC / SEC, on the market
for GPC / SEC, on the market. It measures the intensity of scattering at each angle simultaneously, which in conjunction with a concentration detector is used to calculate absolute molecular weight of proteins, synthetic & natural polymers, and also molecular size expressed as the radius of gyration, Rg.
The SEC-MALS 20 is a modular detector that can easily be used with any existing SEC system, adding the power of light scattering detection for molecular weight and size
measurements. It can also be purchased as part of a complete system package. With a high number of measurement angles and also the best performance at lower angles, the SEC-MALS 20 is superior to traditional MALS instruments. This is achieved using a vertical flow cell with radial optics to minimize the detector noise and maximize the sensitivity.
For proteins SEC-MALS measures the absolute molecular weight independent of column retention volume in order to study oligomeric state and aggregation. In combination with two concentration detectors, SEC-MALS can also measure the molecular weight of conjugates such as PEGylated and detergent soluble proteins.
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Features of SEC-MALS 20
- No column calibration; MW is independent of elution volume * 20 detectors for improved angular coverage * Multiple low angle and low noise detectors to improve accuracy * Single flow cell compatible with all solvent refractive indices * Vertical flow cell with advanced radial optics for improved performance * Compatible with any GPC/SEC system.
General Specifications
Depth | 46 cm |
Height | 16 cm |
Width | 26 cm |
Power Requirements | 60W |
Weight | 16.5 kg |
Additional Specifications
Laser wavelength:
660 nm
Laser power:
120 mW max, 100mW to cell
Laser lifetime:
>10,000 hours
Number of scattering angles:
20
Scattering angle positions:
12, 20, 28, 36, 44, 52, 60, 68, 76, 84, 90, 100, 108, 116, 124,
132, 140, 148, 156, 164°
Cell volume:
63 µl
Scattering volume:
10(7)g/mol*
Molecular weight accuracy:
±2% for NIST standard SRM 1478
Radius of gyration range:
10 – 150 nm*
Limit of quantification:
1Μg Polystyrene 105 kDa
2Μg BSA
Analysis models:
Zimm
Berry
Debye