Wyatt Technology - Möbius
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The Möbius makes reliable, reproducible, and non-destructive electrophoretic mobility and zeta potential me...
The Möbius makes reliable, reproducible, and non-destructive electrophoretic mobility and zeta potential measurements of macromolecules smaller than 2 nm in radius, as well as micron-size nanoparticles, in most aqueous buffers. Thanks to an innovative, highly sensitive electro-optical design incorporating 31 parallel detectors, the Möbius characterizes even fragile biomolecules non-destructively at low applied voltage. An integrated dynamic light scattering (DLS) detector provides simultaneous size measurements in order to monitor potential sample degradation and to calculate zeta potential or surface charge.
The Möbius interfaces with a standard autosampler for high productivity and unattended overnight, multi-sample analyses. The Atlas™ flow cell pressurization system extends the range of accurate, repeatable mobility measurements to difficult samples such as proteins in high-salt buffers up to 1M NaCl. The flow cell volume is just 170 µL, while the sample volume required with the manually-loaded dip cell is as small as 65 µL.
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Features of Möbius
- Mobility: particles from 2 nm to 50 µm, in a pressurizable flow cell or manual dip cell
- Range of hydrodynamic radius Rh: 0.2 nm to 5000 nm in the flow cell, and 0.2 to 200 nm in the dip cell or quartz cuvette
- Sensitivity: 0.05 mg/mL lysozyme (DLS), 1 mg/mL lysozyme (mobility/zeta potential)
- Temperature range: 4°C to 70°C
- DYNAMICS® software provides a comprehensive set of analyses for macromolecules and nanoparticles including size, size distributions, zeta potential and net charge.
General Specifications
| Depth | 59 cm |
| Sample Volume Range | 45 to 170 μL |
| Height | 21 cm |
| Width | 36 cm |
| Power Requirements | 90 - 250V @ 50 - 60 Hz |
| Size | 0.2 to 5000 nm |
| Weight | 24 kg |
| Measurement | 1 to 50 nm |
| Light Source | 50 mW diode-pumped, solid-state, single-longitudinal-mode laser |
Additional Specifications
Mobility Measurements Conductivity Range: 0 - 7 mS/cm; 0-100 mS/cm with Atlas pressurization system Mobility Range: No practical limit Mobility Size Range (radius): 1 nm - 50 Μm Mobility Sensitivity: 1 mg/mL lysozyme (flow cell); 5 mg/mL BSA (dip cell) DLS Size Measurement Size Range (radius): 0.2 - 5000 nm (flow cell); 0.2 - 200 nm (dip cell, quartz cuvette); 0.2-250 nm (disposable cuvette) Detection Angle: 163.5° Size Sensitivity: 0.05 mg/mL lysozyme* Attenuation: Maximum Detector Auto-attenuation 3000x Sample Cells Flow Cell (PALS + DLS): 170 µL PEEK flow cell for aqueous and most organic solvents. Required for autosampler and/or Atlas operation. Dip Cell (PALS + DLS): Quartz cuvette + PEEK & platinum dip probe. For manual sample introduction; cannot be pressurized. Requires 65 µL of solution for PALS or 45 µL for DLS measurements. Quartz Cuvette (DLS Only): 45 µL quartz cuvette. Disposable Cuvette (DLS Only): 100 µL polystyrene cuvette. Sample Temperature Control: 4 -70°C Optics Light Source: 50 mW diode-pumped, solid-state, single-longitudinal-mode laser Laser Wavelength: 532 nm. Please inquire regarding other wavelengths. Laser Lifetime: > 10,000 hours Detectors: 32 detector channels for multi-angle PALS detection Wetted Materials: 316 stainless steel, PEEK, quartz or glass, platinum, Kalrez