The IdeS Protease can be used to characterize therapeutic antibody candidates using LC/MS
The IdeS Protease can be used to characterize therapeutic antibody candidates using LC/MS. The Promega IdeS Protease is a recombinant, engineered version of the enzyme from S. pyogenes and contains a histidine tag for easy removal.
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Features of IdeS Protease
Fast and Easy: Digestion in 30 minutes with no optimization. Highly Reproducible and Specific: Cleaves exclusively at a single site below the hinge to produce F(ab′)2 and Fc fragments. High Performance: Essentially 100% complete digestion. Versatile: Effectively cleaves human, monkey, sheep, rabbit, humanized and chimeric IgGs, as well as Fc-fusion proteins.
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