MilliporeSigma - Magna Nuclear

Manufactured by  MilliporeSigma
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Magna RIP RNA-Binding Protein Immunoprecipitation Kit containing all necessary reagents to perform 12 individual RNA-binding reactions.

RNA-binding protein immunoprecipitation (RIP) is the RNA analog of the more well-known ChIP application (chromatin immunoprecipitation), which identifies DNA targets of DNA-binding proteins in an in-vivo cellular context. RIP can be used to identify specific RNA molecules (of many types) associated with specific nuclear or cytoplasmic binding proteins. These experiments involve immunoprecipitation of endogenously formed complexes of RNA-binding proteins and co-isolation of any RNA species associated with that RNA-binding protein. Purification of these RNA species allows interrogation and identification of mRNAs (and potentially non-coding RNAs associated with them) and can be directly measured using down stream applications including quantitative reverse transcription polymerase chain reaction (RT-PCR), microarray analysis (RIP-chip) and “deep-sequencing” or 2nd-generation sequencing based platforms (RIP-Seq).
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Features of Magna Nuclear
  • Facilitates isolation and analysis of RNA molecules associated with chromatin   * Available for native or cross-linked chromatin for analysis of both high- and low-affinity interactions   * Compatible with both RT-qPCR or RNA-seq   * Protein A/G magnetic beads, optimized to bind nucleic acid-protein immune complexes   * RNAse inhibitors and RNAse-free reagents   * Negative controls
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