inSphero - 3D InSight™ Multi-donor Human Liver Microtissues

Manufactured by  inSphero
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3D InSight™ Multi-donor Human Liver Microtissues offer structural and functional robustness of our single-donor microtissues.

3D InSight™ Multi-donor Human Liver Microtissues offer the same structural and functional robustness of our single-donor microtissues, but offer a more diverse genetic background to help mitigate potential bias in a single-donor microtissue originating from CYP polymorphisms. By pooling hepatocytes from 5 male and 5 female donors, multi-donor microtissues more closely approximate the average human response, and extend donor lot availability to ensure a long-term supply of donor material. Available as co-cultures with Kupffer cells, or as hepatocyte monocultures, multi-donor microtissues are ideal for in vitro DILI detection and prediction, compound toxicity screening, mechanistic tox studies, and DMPK.
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Features of 3D InSight™ Multi-donor Human Liver Microtissues
  • Pool of 10 individual donors better reflects average response of a population * Co-culture with Kupffer cells for highest biological relevance * Organotypic, functional liver model suited for testing over extended time period
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