Teledyne Isco - CombiFlash® Rf+

Manufactured by  Teledyne Isco
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RFID method automation, more fractions, larger screen, higher pressure – all in a smaller package.

The CombiFlash® Rf+ improves your productivity whether you purify synthetic compounds, natural products, peptides, or polymers. With operating pressures up to 200 psi (13.8 bar) the CombiFlash Rf+ is compatible with both normal and reversed phase purification conditions. 
 
The TLC to Gradient calculator automatically determines optimal separation parameters while minimizing run time. 
 
There is no need to wait to access data - built in networking allows you to connect to the CombiFlash® Rf+ to monitor and remotely control your experiment, analyze data, and print to network printers. 
 
View UV spectra in real time - during peak elution. Review the spectra to confirm that the system is monitoring the correct wavelength. Interactive screen lets you change parameters instantly during the run if another wavelength would be more appropriate. 
 
Rapid column air purge prevents solvent from being discarded with the used column. It is better for the environment, safer in the lab, and eliminates messy column removal. 
 
Easy scale-up with built-in method-scaling means you won't need to re-develop your method. You save time when you increase reaction size. You can even scale up to a 3 kg column run on a CombiFlash Torrent.
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Features of CombiFlash® Rf+
  • One simple push of a button and your purification is underway. 
  • UV Spectra display in real time and post run. 
  • Compact design saves valuable bench or hood space. 
  • RFID (Radio Frequency Identification) technology automates setting the parameters for purification runs and fraction collection. 
  • Built-in solvent and waste management prevents columns from drying, and messy waste overfills. 
  • Large 10.4" (26.4cm) touch screen provides a simple to use and informative user interface through our intuitive PeakTrak software.
  • General Specifications
    Depth 17 in
    Height24 in
    Width 14.1 in
    Weight54 lbs
    Additional Specifications

    Controller 
    10.4 inch touchscreen (26.4 cm), or external web browser via Ethernet. Data and current run can be accessed by up to 10 remote computers. Front panel USB port to save data and transfer files. 
    PeakTrak software for 
    On-screen method development; Real-time control - change method parameters during a run without pausing; Converting Rf values into solvent gradients; Method scaling -transfer method from one size column to another, from 4 g to 330 g; Converting methods to 3000 g columns for operation on CombiFlash Torrent; Color-coded fraction identification. 
    Remote Wireless Access 
    Monitor system operation while away from the lab using iPad, iPhone, or iPod. Change conditions on the fly. 
    Programmable gradients 
    Linear and/or step gradients. Change profiles anytime during run, using "Click and drag" gradients. Pause gradient for isocratic hold. 
    Pumping system 
    Positive displacement pumps. 1-200 mL/min. 0-200 psi (when used with RediSep Rf columns) 
    Number of Solvents 
    Binary gradient with any two of four solvents; A third solvent can be used to add modifier at a fixed percentage. 
    Gradient Formation 
    Low pressure gradient formation, Accuracy <2% full scale; Linear, step, isocratic mixing capability 
    Auto-Method (RFID) 
    RFID column detection, RFID Test Tube Rack identification 
    Column sizes 
    4 g to 330 g 
    Fraction collection 
    Internal fraction collector capacity- 13x100 mm tubes - 216, 16x125/150 mm tubes - 150, 18x150/180 mm tubes - 140, 25x150 mm tubes - 60, 40 mL scintillation vials - 60, 20 mL scintillation vials - 54, 480 mL bottles - 12. 
    Fraction Size 
    Determined by peak cutting and by user-defined maximum tube volume 
    Sample injection 
    Auto-inject with 6-position automated motorized sample loading valve; self-cleans at end of run; solid or liquid injection 
    Detection 
    Software selectable variable wavelength UV, 200-400 nm; optional variable wavelength UV-Vis, 200-800 nm; slope and threshold peak detection; detector range 0.2-2.4 AUFS; determination of peak purity by wavelength ratios. 
    Safety 
    Static dissipating tubing, vapor sensor, and column air purge. 
    Sample security 
    Auto-run extension at end of run, and over pressure sensor. 
    Solvent management 
    Four solvent and one waste fluid level monitoring

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