Waters - ProteinWorks
Reproducible and Standardized Protein Quantification with a Simplified Kit-Based Approach
With ProteinWorks, achieve:
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Features of ProteinWorks
Reproducible
Optimized kit-based approach delivers mean % of < 6% using multiple peptides for 4 representative mAbs in plasma * Streamlined protocol reduces the number of sample preparation steps * Inter-kit and intra-kit precision ensures reproducible results, day to day, lab to lab, and analyst to analyst
Sensitive * High sensitivity detection limit of 10 ng/ml was achieved for infliximab in rat plasma * Kits are optimized for the digestion of whole plasma or immunopurified samples * uElution SPE improves assay sensitivity through sample concentration and the removal of salts, phospholipids, and residual digestion reagents
Standardized & Simplified Broadly applicable protocol eliminates Method Development for Discovery Studies Kit-based approach is easily deployable from lab to lab, site to site, and sponsor to CRO Simple, well-defined protocols and pre-measured lot-traceable reagents facilitate method transfer and provide a well-researched starting point for those new to protein bioanalysis
Flexible * Convenient flexible format easily accommodates 1-96 samples with (12) strips of (8) 1 mL tubes * For optimal results, 3 and 5 step protocols offer the choice to reduce and alkylate, or not * 96-well format is easily automatable
For Post-Digestion Sample Clean-Up, use the ProteinWorks uElution SPE Kit (sold separately or included in ProteinWorks eXpress Digest and eXpress Direct Digest Start-up Kits)
Optional intact murine mAb standard is ideal for workflow training and system health checks (sold separately or included in ProteinWorks eXpress Digest and eXpress Direct Digest Start-up Kits)
General Specifications
There are no General Specifications available.