Uses of Patient Derived Xenograft     
     
Patient Derived Xenograft models are typically implanted as dissociated cells or tumor fragments into immunodeficient mouse models which may then be used for in vivo efficacy studies, allowing you to accelerate your oncology research or drug discovery and development programs, including applications for:     
     

Preclinical drug screening     

Preclinical combination therapeutics screening     

Identification and analysis of biomarkers     
     

PDX Products and Services     
Horizon offers our cancer model collections as ungrafted PDX suspensions or as comprehensive in vivo efficacy studies.     
     
For services, simply provide us with your test articles, and our team of experienced scientists will demonstrate their effect on PDX grown in immunodeficient mice. Horizon’s offerings and capabilities include:     
     

Frozen, ungrafted live PDX tumor suspensions or fragments for use in your facility     

In vivo efficacy studies conducted at our facility     

Ex vivo efficacy studies conducted at our facility     

Snap-frozen and/or FFPE material from PDX tumors for analysis (subject to availability)     

Horizon also offers tolerability studies and PK/PD studies at our facility to help you build the right experiment