Controlled nucleation is becoming an important step in a freeze drying cycle and our development work with ControLyo® has shown significant benefits.
Controlled nucleation is becoming an important step in a freeze drying cycle and our development work with ControLyo® Technology has shown significant benefits. Its function is to control the nucleation of the product solution in the freeze dryer, i.e. the solution in all vials (or bulk, syringes, etc.) allowing nucleation at the same time and the same temperature, which is predefined by the researcher. This is key to reducing cycle times and providing a cycle design which can be reproduced from one freeze dryer to another. In short, ControLyo® Technology delivers a controlled process, improves product quality, shortens drying times, and requires no formulation change or introduction of foreign material into the vials.
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