In native chromatin the proteins and histones wrapped around DNA are naturally linked and the traditional methods of shearing can easily disrupt the DNA- protein complexes. Therefore the DNA is biologically sheared using enzyme digestion of the chromatin. This kit can be can be used for the study of histone modifications and certain abundant transcription factors that are likely to be bound to DNA.  
 
Chromatrap® Native ChIP kits provide a quicker, easier and more efficient way of performing ChIP assays from native chromatin. Using the unique patented technology maximises the capture efficiency of the target chromatin/antibody complex. By avoiding the use of magnetic or agarose beads, non-specific background is eliminated together with reduced manual handling errors and subsequent sample loss.