Horizon - Alpha-Synuclein A53T SNCA Knock-in Rat
Manufactured by Horizon
Developed in collaboration with The Michael J. Fox Foundation, this model contains a knockin of the A53T-mutated SNCA...
Developed in collaboration with The Michael J. Fox Foundation, this model contains a knockin of the A53T-mutated SNCA gene deeming the rat SNCA gene non-functional. The knockin contains humanized amino acids for the region spanning amino acids 53-122. The resulting model expresses a humanized A53T alpha-synuclein protein without endogenous rat alpha-synuclein. This model was generated using CRISPR/Cas9 genome targeting strategies. The A53T mutation in the SNCA gene has been linked to early-onset Parkinson’s disease (PD), making this model useful for understanding alpha-synuclein biology and PD pathogenesis.
Active Questions & AnswersAsk a Question
There are no current Discussions
Need Equipment Support?
Documents & Manuals
There are no Documents or Manuals available.
Features
There are no Features available.
General Specifications
There are no General Specifications available.