Malvern Panalytical - MicroCal PEAQ-DSC Automated

Manufactured by  Malvern Panalytical
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The MicroCal PEAQ-DSC Automated system delivers high throughput, highly sensitive protein stability analysis with low sample consumption.

The MicroCal PEAQ-DSC Automated system delivers high throughput, highly sensitive protein stability analysis with low sample consumption, in an automated, integrated platform for increased productivity. All cell filling and cleaning functions are fully automated for walk-away operation.   
Data generated by the MicroCal PEAQ-DSC Automated provide critical guidance for biopharmaceutical development in protein engineering, (pre)formulation development, process development, manufacturing change control and biosimilarity and biocomparability studies. Unattended operation enables 24-hour screening, while the integrated software streamlines workflows, facilitates non-subjective data analysis, performance qualification and compliance with 21 CFR Part 11 and Annex 11 regulations, all delivering high integrity data and driving productivity in biopharmaceutical research.   
Differential Scanning Calorimetry (DSC) is a powerful analytical tool for characterizing the thermal stability of proteins and other biomolecules. The technique measures the enthalpy (ΔH) and temperature (Tm) of thermally-induced structural transitions of molecules in solution. This information provides valuable insights into factors that stabilize or destabilize proteins, nucleic acids, micellar complexes and other macromolecular systems. The data are used to predict shelf-life of biomolecular products including biopharmaceuticals to enable batch-to-batch and biosimilar versus innovator molecule comparisons, to develop purification strategies, to characterize and evaluate protein constructs, and to rank the affinities of ligands to their protein targets in small molecule drug discovery programs.   
The high-throughput, high-sensitivity MicroCal PEAQ-DSC Automated system features software that streamlines workflows through simplified experimental setup and flexible instrument scheduling. Automated data analysis supports the generation of high integrity thermal stability data and delivers compliance with regulatory requirements, whilst allowing easy integration into existing data handling and transfer systems.
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Features of MicroCal PEAQ-DSC Automated
  • Gold standard stability-indicating technique requiring minimal assay development    * Direct and label-free measurement of biomolecular native-state stability in solution    * Standard 96-well plate format for high capacity and easy loading, with thermostatically-controlled storage of up to 6 plates   * Fully integrated autosampler enables unattended analysis of up to 50 samples per day   * Automated cell filling and cell cleaning functions permit unattended operation    * Measurement of very tight binding constants, up to 1020M-1
General Specifications

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Additional Specifications

Technology : Differential Scanning Calorimetry    
Measurement type : Temperature midpoint (TM) Enthalpy (ΔH)Heat capacity change (ΔCp)   
Cell : Capillary    
Cell material : Tantalum    
Cell volume : 130 ΜL   
Sample capacity : 288 (6 × 96-well plates)    
Sample volume : 325 µL    
Typical sample concentration : 0.01 mg/mL – 10 mg/mL 1    
Sample throughput : ?50 samples/day    
Sample storage temperature range : 4°C - 40°C   
Noise : 0.05 ΜCal/°C 2    
Baseline repeatability : 1 ΜCal/°C 2    
Response time : 5s 2 Repeatability : <0.2 µCal/°C 3    
Reproducibility : <0.08°C St. Dev. TM and <2% RSD on ΔH 4    
System reproducibility : <0.1°C St. Dev. TM and <5% RSD on ΔH 4    
Multiple feedback modes : Yes (passive, high gain and low gain)    
Temperature range : 2°C to 130°C 2, 5    
Maximum scan rate : 240°C/h    
Reverse scanning : Yes    
Pressure perturbation calorimetry (PPC) : N/A    
Cleaning routines : 3 pre-programmed routines    
Cleaning solvents : Water and detergent used as standard   
21 CFR part 11 : Yes, with PEAQ-Compliance software option    
Network ready : Yes, with email alert capability   
Operating temperature (°C) : +10°C to +28°C    
Storage temperature : -20°C to +50°C    
Humidity : 10% to 70%, non-condensing (10% to 90% for storage)    
Ingress Protection (IP) rating : IP21    
Power : 100-240 V A/C, 50/60 Hz, 70 W (cell), 400 W (max, autosampler), PC as supplied    
Certification : CE (EN61010-1), EMC (EN61326-2-1, EN61326-1, FCC, ICES, VCCI), ISO9001:2008   
Dimensions (W, D, H) : 101 cm × 68 cm × 70 cm    
Weight : Approx. 25 kg

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