Morphologi 4-ID delivers detailed component-specific morphological descriptions of particulate blends through Morphologically-Directed Raman Spectroscopy (MDRS). This combines automated particle imaging with Raman spectroscopy in a single, integrated platform, providing the power to unlock complex particle characterization problems.

Overview

• Patented MDRS capability delivers representative component-specific particle size and shape data, delivering full characterization of your sample
• All the functionality of the Morphologi 4 combined with a dedicated Raman platform for both physical and chemical particle characterization in a single, automated measurement
• Automatically measures Raman spectra for hundreds or thousands of particles, saving valuable analyst time
  Intuitive software ensures suitability for experienced and non-experienced spectroscopists alike
• Easy correlation of morphological properties with chemical information provides the most comprehensive understanding of your sample
• 21 CFR Part 11 software option ensures regulatory compliance
• Adaptable workflows enable methods to be tailored to specific user or application requirements.
• Select particles for chemical analysis:
  • manually, from particle images
  • morphologically-directed, based on user-specified classifications (MDRS)
  • automatically and objectively by the software
• Ability to export spectra in industry-standard format supports unknown component identification using 3rd party spectral libraries
• Tight control of laser power and acquisition time enables measurement optimization for a wide range of materials, from weak Raman scatterers to those that are thermally sensitive

The Morphologi 4-ID measurement procedure can be split into five sections:

Sample preparation

Spatial separation of individual particles and agglomerates is critical to robust results. The integrated dry powder disperser makes preparing dry powder samples easy and reproducible. The applied dispersion energy can be precisely controlled, enabling the measurement process to be optimized for a range of material types. Accessories that fit directly in to the Morphologi 4-ID’s automated stage are available for preparing suspended or filtered samples.

Image capture

The instrument captures images of individual particles by scanning the sample underneath the microscope optics. The Morphologi 4-ID can illuminate the sample from below or above, whilst accurately controlling the light levels.

Image processing

Use of either the automated ‘Sharp Edge’ segmentation analysis or the manually-controlled thresholding enables the detection of particles and the calculation of a range of morphological parameters for each.

MDRS

Components and particles of interest are targeted for Raman analysis. Particles can be selectively targeted based on their morphology, or particles representative of the whole sample can be targeted objectively by the Morphologi software.

Result generation

Advanced graphing and data classification options in the software ensure that extracting the relevant data from the measurement is straightforward, via an intuitive visual interface. Correlation scores to a reference library are calculated for each Raman spectrum acquired, enabling particles to be classified based on their chemistry. The morphological data associated with the particles in each chemical class is used to generate size and shape distributions, delivering component-specific morphological information. Individually-stored grayscale images for each particle are linked to their Raman spectra and provide qualitative verification of the quantitative results.