Optics          The Twinkle LB 970 Fluorometer provides highest sensitivity due to Single Photon Counting technology and extremely low noise Photomultiplier. For excitation a Tungsten halogen lamp is used. The instrument is standard equipped with filter pairs for FITC and Umbilliferone.          Instrument          The fluorescence reading can be taken from the bottom or the top. The bottom reading is instrument of choice for measurements of adherent cells, coloured medium and lids to achieve the most efficient detection. The instrument can be equipped with temperature control to establish ideal conditions for all cell based applications.          Software          Especially in cell applications samples are heterogenously spread in the well. To measure the complete area, up to 100 individual measuremet points can be defined within the same well. For dual ratio measurements you can define two excitation/emission filters for one label. The instrument will carry out the measurements sequentially by plate. Kinetic measurements can be performed up to 24 hours.          Shaking          3 modes each with variable speed of the integrated shaker to enhance mixing and optimise sample distribution before measurement in long term kinetics.          Stacker & Robotic integration          Specially designed for but not restricted to the use in HTS departments of drug discovery companies the robot access module allows for uncomplicated integration of the Twinkle into any type of lab automation system. Software and hardware easily integrate into existing robotic or liquid handling systems. A barcode reader is available on request for positive plate identification.          The Stacker unit LB 931 will complete the Twinkle LB 970 fluorometer in terms of throughput. The instruments can be used as a stand alone unit, equipped with the 25 or 50 plate stacker or any other robot system.          Applications    

    
• Binding studies    
• Cell proliferation    
• DNA quantification    
• Drug screening    
• Enzyme kinetics    
• Environmental toxins    
• FRET    
• Immunoassays    
• Phagocytosis    
• Protein concentration    
• Reporter gene assays