Microfluidics - Pilot Scale

Manufactured by  Microfluidics
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PILOT SCALE M-110EH Microfluidizer processor for Continuous, High Shear Fluid Process...

PILOT SCALE M-110EH Microfluidizer processor for Continuous, High Shear Fluid Processing   
Utilizing Microfluidizer fixed-geometry interaction chamber technology and a ceramic (Zirconia) plunger, the M-110EH processes a wide variety of fluids such as simple oil-in-water emulsions, solids-in-liquid suspensions and cell disruptions — including the most difficult yeasts and plant cells — in one or two passes. Most importantly, the process is repeatable and is guaranteed to scale up to production volumes.   
   
M-110EH Biopharma Microfluidizer processor for Processing Clinical and Small Production cGMP Batches   
The M-110EH models were designed to bridge the gap between the biopharma lab scale (M-110P) and production scale (M-700 series) models, and they are ideal for manufacturing batches necessary for PHII and PHIII clinical trials. Units are available in basic, enhanced and aseptic models. The M-110EH processor is available with Steam-in-Place for aseptic processing, Ultra Clean-in-Place to eliminate the need for disassembly, and Clean-out-of-Place. Data recording and validation support documentation ensure compliance with 21 CFR Part 11 guidelines.   
   
M815 Microfluidizer for Processing Pilot Scale and Small Production Batches   
The M815 models were designed to bridge the gap between the lab scale (M-110EH) and production scale (M-700 series) models, and they are ideal for manufacturing batches in the range of 100L-300L   
   
RECOMMENDED USES   
The pilot-scale M-110EH is recommended for:   
   
  • Particle Size Reduction for Submicron and Nano-Sized Particles   
  • Deagglomeration   
  • Cell Disruption   
  • Immiscible Liquid Emulsions   
  • Solid-in-Liquid Suspensions   
  • Liposomes
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    Features of Pilot Scale
    • Handles minimum sample sizes as small as 120 ml   * Achieves processing pressures up to 2068 bar (30,000 psi)   * Produces flow rates up to 330 ml/min at 2068 bar (30,000 psi) or 450 ml/min at 1724 bar (25,000 psi)   * Guarantees scaleup to production   * Features an on-board heat exchanger for consistent discharge product temperature   * Is designed for Clean-in-Place with no disassembly required   * Is available with Steam-in-Place (SIP) option   * Is available with optional explosion-proof design   * Meets CE compliance standards (Europe)   * Patented, wear-resistant diamond interaction chamber — no moving parts   * Ceramic Auxiliary Processing Module (APM)   * Ceramic (Zirconia) plunger for extended seal life   * Stainless steel enclosure   * Electric hydraulic power unit   * Gauges for measuring process pressure, hydraulic drive pressure, and hydraulic oil level and temperature   * Portable self-contained unit, mounted on locking casters   * Feed temperature range 16?C – 75?C (35?F – 165?F)   * TEFC (totally enclosed fan-cooled) motor, starter, controls and power cord
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