DeNovix Inc. - CellDrop Cell Counters

Manufactured by  DeNovix Inc.
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Count Cells Without Slides

CellDrop™ Automated Cell Counters feature patented DirectPipette™ Technology to eliminate plastic slides and cumbersome hemocytometers from routine cell counting. CellDrop™ Cell Counters feature dual fluorescence and brightfield optics, variable height sample chamber, and powerful, easy-to-use analysis software. The instruments enable the fastest cell counts, viability assessment, and GFP transfection efficiency measurements across the widest range of cell density, cell type and application.

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Features of CellDrop Cell Counters

The CellDrop™ Automated Cell Counter Series brings the familiar Load, Measure & Wipe Clean functionality of microvolume spectrophotometers to cell counting. Traditional plastic slides or glass hemocytometers are replaced by two permanent optical sapphire surfaces. These are positioned parallel to one another by a calibration-free, high-precision mechanism, forming a chamber of precisely defined height. 10µL of cell suspension is pipetted into the chamber, analyzed and simply wiped away with a dry laboratory wipe. The powerful live-view image allows instant verification that cleaning has been successful. 

Accurate Across the Widest Range of Cell Size and Density

Using conventional counting methods, samples with high or low cell densities require time consuming dilution or concentration steps. The variable height chamber of the CellDrop™ Automated Cell Counters enables the most accurate counts over the widest cell densities – 7 x 102 – 2.5 x 107 cells/mL. Chamber height can also be adjusted to accommodate almost any cell with a diameter range of 4 to 400µm.

Easy-to-Learn, Powerful-to-Use

Designed by life scientists, the CellDrop EasyApps® Software exceeds the functionality of high cost cell counters while also delivering the ease-of-use of simpler systems. EasyApps and the high definition, 7″ touchscreen interface provides intuitive cell counting, from sample loading to data exporting in seconds. Pre-installed applications include a range of common applications for one-touch analysis of assays such as Brightfield, Trypan blue, AO/PI, GFP and Yeast and the ability to create custom methods. CellDrop™ Cell Counters are a flexible workhorse for the busy, multi-user lab.

Cell Size Histograms allow easy gating for non-target cells or cell debris. Simply drag the slider to set the cell size of interest.

High Definition cell outlining and declustering algorithms developed by DeNovix provide high accuracy cell counts of regular and irregular cells even at high density

Viability measurements of PBMCs in the presence of debris and red blood cells. The unique combination of flexible hardware and custom software ensures compatibility with a broad range of cells and assays.

Automatically calculate cells / mL and % viability along with a range of useful cell metrics. Add dilution calculations to your protocols to calculate volumes of cells and buffer required to meet target cell densities.

Flexible reporting options allow easy exporting in a format to suit each lab member. Email results, print to a network printer or save to a USB drive. Results are saved to a built-in solid state drive for extra data security.

21 CFR Part 11 Compliance Ready

EasyApps Secure provides an optional suite of software controls that allow regulated GxP facilities to easily add CellDrop to their cell counting workflow (view the compliance statement). The software is fully integrated within the on-board operating system and includes a range of features essential to ensuring compliance, including:

  • Password protected system access
  • Integrated electronic signature controls
  • Comprehensive user account management
  • Secure audit trail recording
  • Advanced data handling and export tools

Hazardous Samples?

The small footprint and onboard processing of the CellDrop™ Cell Counter allow it to fit inside most flow hoods where required. For applications that require the cells to be contained when reading, all instruments also have the ability to read samples in common disposable plastic slides and reusable slides without the need for additional adaptors.

Models

CellDrop™ is available in Dual Fluorescence and Brightfield (CellDrop™ FL) or Brightfield only (CellDrop™ BF) models, each with the option of Unlimited Counts or Pay-As-You-Go.

| Part Number | Description | | --- | --- | | CellDrop™ FL-UNLTD | 2 Channel Fluorescence Cell Counter with Unlimited Counts | | CellDrop™ FL-PAYG | 2 Channel Fluorescence Cell Counter- Pay-As-You-Go | | CellDrop™ BF-UNLTD | Brightfield Cell Counter with Unlimited Counts | | CellDrop™ BF-PAYG | Brightfield Cell Counter- Pay-As-You-Go |

Patents US 10,302,568 Japan 6579475

General Specifications

There are no General Specifications available.

Additional Specifications

CellDrop™ Specifications

Dynamic Range7 x 102 – 2.5 x 107 cells/ml 
Cell Size Range4 – 400 µm
Sample Volume5.0 µL @50 µm chamber height
10 µL @100 µm chamber height (standard)
40 µL @400 µm chamber height
Measurement SpeedBrightfield- 3 seconds @1 x 106 cell/mL
Dual Fluorescence- 8.5 seconds @1 x 106 cell/mL
Optical ModesCellDrop™ FL – Dual Fluorescence, Single Fluorescence, Brightfield, Fluorescence + Brightfield
CellDrop BF – Brightfield only
Sample SurfacesOptical Sapphire
Brightfield IlluminationLED 530 nm
Fluorescence IlluminationLED 470 nm
Emission Filters530 nm +/- 25 nm
645nm +/- 37 nm
Gesture RecognitionMultipoint touch, swipe, pinch
Display7″ HD Touch Screen
Glove CompatibilityAll common laboratory gloves


Images2048 x 800 px (3.15 MB) with overlay capabilities
FocusUser-controlled onscreen coarse and fine adjustment
DetectorCellDrop™ FL – Sony IMX265
CellDrop™ BF – ON Semiconductor MT9P031


ConnectivityWiFi, Ethernet, HDMi, USB
Footprint (LxWxH)37 x 21 x 18 cm
Weight8 Kg
Operating Voltage12 VDC
ApprovalsUL/CSA, CE, FCC, Japan CAB
Manufacturer LocationUSA
Warranty2 Years
ColorsArctic White
Internal Storage120 GB solid state drive – upgradable to 1 TB
AccessoriesLabel Printer, barcode reader, keyboard, mouse, 20 µL pipette

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