BMG LABTECH - BMG LABTECH - CLARIOstar Plus
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CLARIOStar Plus flexible, sensitive microplate reader.
The CLARIOstar® is BMG LABTECH’s most flexible microplate reader, equipped with our revolutionary LVF monochromator™technology. A combination of monochromators, filters, and spectrometer means that it does not compromise on sensitivity or flexibility. As well as its high performance in all detection modes, the CLARIOstar’s versatility also makes it ideal for assay development.
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Features of BMG LABTECH - CLARIOstar Plus
Accessories
- Atmospheric Control Unit (ACU): provides the ideal environment for cell-based assays by regulating O2 and CO2 gas levels in the microplate reader
- Filters and Optic Modules: standard filters from 240 - 850 nm, filters and Optic Modules optimised for specific applications, and bespoke solutions are available
- Microplate Stacker: optimises microplate handling and increases throughput by providing rapid loading, unloading, restacking, and continuous feeding for up to 50 microplates
- LVis Plate: microplate for low-volume DNA, RNA and protein quantification. It includes 16 micro-drop (2 µL) wells, a cuvette slot and optional performance testing features
- Evaluation Plate: validates the optical functionality of BMG LABTECH microplate readers for quality control and/or qualification (IQ/OQ) purposes
General Specifications
There are no General Specifications available.
Additional Specifications
Detection Modes
Fluorescence intensity (incl. FRET)
Fluorescence polarization
AlphaScreen®/AlphaLISA®/AlphaPlexTM
Luminescence (flash and glow) - incl. BRET
Time-resolved fluorescence
TR-FRET
UV/Vis absorbance spectra
Measurement Modes
Top and bottom reading
Endpoint and kinetic
Sequential multi-excitation
Sequential multi-emission
Spectral scanning (fluorescence, luminescence, absorbance)
Ratiometric measurements
Well scanning
Microplate Formats
6- to 1536-well plates, user-definable
LVis Plate with 16 low volume microspots (2 μL)
Microplate Carrier
Robot compatible
Light Sources
High energy xenon flash lamp
Dedicated laser for AlphaScreen®/AlphaLISA®/AlphaPlexTM
Detectors
Low-noise photomultiplier tube
CCD spectrometer
Wavelength Selection
Dual Linear Variable Filter (LVF) Monochromators™
Linear Variable Dichroic Mirror
Separates ex & em LVF Monochromators
Optical filters:
Ex and em slides hold 4 filters each
LVF Monochromators + optical filters
Use one for ex and the other for em
UV/Vis absorbance spectrometer:
Full spectra or 8 distinct wavelengths in < 1 sec/well
Optical Filters
Excitation and emission slides for 4 filters each
Optical Path Guides
Top and bottom: free-air optical light path guided by motor-driven mirrors and dichroics
Z-Adjustment
Automatic focal height adjustment (0.1 mm resolution)
Spectral Range
Filters
240 - 750 nm or 240 - 900 nm for FI, FP, TRF
240 - 750 nm for LUM
LVF Monochromators™
320 - 850 nm for FI
320 - 750 nm for LUM
Linear Variable Dichroic
340 - 740 nm for FI, LUM
Spectrometer
220 - 1000 nm for ABS
Sensitivity
FI filters < 0.15 pM (< 3 amol/well FITC, 384sv, 20 μL)
(top)
FI filters < 1.0 pM (< 50 amol/well FITC, 384g, 50 μL)
(bottom)
FI monochromator < 0.35 pM (< 7 amol/well FITC, 384sv, 20 μL)
(top)
FI monochromator < 3.0 pM (< 150 amol/well FITC, 384g, 50 μL)
(bottom)
FP < 0.5 mP SD at 1 nM FITC (384sv, 20 μL)
HTRF®
(black and white microplates)
Reader Control Kit (Eu) after 18h (384sv, 20 μL)
Delta F > 880 % (High Calibrator)
Delta F > 30 % (Low Calibrator)
TRF < 20 fM europium, 384, 80 μL
LUM < 0.4 pM (< 8 amol/well ATP, 384sv, 20 μL) Dynamic range: 9 decades
AlphaScreen®
with laser < 5 pM (< 100 amol/well P-Tyr-100, 384sv, 20 μL)
ABS
with spectrometer
Full spectrum captured in < 1 s / well
Selectable spectral resolution: 1, 2, 5, and 10 nm
OD range: 0 - 4 OD
Accuracy: < 1% at 2 OD
Precision: < 0.5% at 1 OD and < 0.8% at 2 OD
Read Times
Flying mode (1 flash) 8 s (96), 15 s (384), 28 s (1536)
19 s (96), 57 s (384), 3 min 4 s (1536)
Reagent Injection
Up to 2 built-in reagent injectors
Individual injection volumes for each well: 3 to 500 µL (optionally up to 2 mL)
Variable injection speed up to 420 µL / s
Reagent back flushing
Shaking
Linear, orbital, and double-orbital with user-definable time and speed
Incubation
+3 °C above ambient up to 45 °C or 65 °C
The upper heating plate of the incubation chamber operates at 0.5 °C more than the lower plate. This prevents condensation build-up on the lid or sealer.
Software
Integrated fluorophore library
Multi-user Reader Control and MARS Data Analysis Software included
FDA 21 CFR Part 11 compliant
Dimensions
Width: 45 cm, depth: 51 cm, height: 40 cm; weight: 32 kg