BMG LABTECH - BMG Labtech - NEPHELOstar Plus
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The world's first and only laser-based microplate nephelometer.
The world’s first and only laser-based microplate nephelometer was developed to meet high-throughput demands for fast compound solubility screens. The NEPHELOstar® Plus detects insoluble particles in liquid samples by measuring forward scattered light and can be used for turbidity measurements, drug solubility screening, protein binding kinetics, microbial growth, and petroleum process control.
The NEPHELOstar Plus is a microplate nephelometer with a high-intensity laser diode. It can be up to thirty times more sensitive than traditional transmission optical density readers that measure the reduction in direct light passing through a sample well. Thanks to its speed, flexibility and performance, the NEPHELOstar Plus allows more applications to be adapted to microplate-based laser nephelometry than ever before.
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Features of BMG Labtech - NEPHELOstar Plus
- Adjustable laser intensity and beam diameter
- Measurement in up to 384-well microplate format
- Incubation up to 45°C or 60°C
- Linear, orbital and double-orbital shaking
- High-precision injectors with simultaneous reagent injection and detection
- Microplate Stacker and robot compatible
General Specifications
There are no General Specifications available.
Additional Specifications
Detection Modes
Nephelometry (light scattering)
Measurement Modes
Endpoint and kinetic
Microplate Formats
Up to 384-well plates
Microplate Carrier
Robot compatible
Light Sources
Self-monitoring laser diode
Wavelength 635±10 nm
Stability <0.2% deviation
Lifetime 20,000 hours
Output: 1 mW
Selectable beam width: 1.5 to 3.5 mm
Selectable intensity 0-100%
Scattering angle: detects up to 80° full cone angle
Detectors
Side window photodiode detector
Wavelength Selection
Photodiode
Wavelength 635±10 nm
Sensitivity
Depends on particle size and liquid properties
Silica detection (particle size 0.5 to 10 µm) 800 nM
Dynamic Range: 5 decades
Maximum count rate (2,000,000 Relative Nephelometry Units (RNUs) per second)
Read Times
Depend on assay conditions and liquid surface stability
Shortest times possible: 16 s (96), 47 s (384)
Reagent Injection
Up to 2 built-in reagent injectors
Injection at measurement position (6 to 384-well)
Individual injection volumes for each well (3 to 500 µL)
Variable injection speed up to 420 µL / s
Up to four injection events per well
Reagent back flushing
Shaking
Linear, orbital, and double-orbital with user-definable time and speed
Purge Gas Vent
System to inject an atmosphere or to pull a vacuum into the reader
Incubation
+4°C above ambient up to 45°C or 60°C
The upper heating plate of the incubation chamber operates at 0.5°C more than the lower plate. This prevents condensation build-up on the lid or sealer.
Software
Multi-user Reader Control and MARS Data Analysis Software included
FDA 21 CFR Part 11 compliant
Dimensions
Width: 44 cm, depth: 48 cm, height: 32 cm; weight: 25 kg
Optional Accessories
Stacker
Magazines for up to 50 plates - continuous loading feature
THERMOstar
Microplate incubator and shaker
Upgrades
Please contact your local representative for upgrades including options such as detection modes, reagent injectors, etc.
- Atmospheric Control Unit (ACU): provides the ideal environment for cell-based assays by regulating O2 and CO2 gas levels in the microplate reader
- Only for CLARIOstar, VANTAstar, FLUOstar, SPECTROstar Omega, LUMIstar Omega, NEPHELOstar Plus
- Filters and Optic Modules: standard filters from 240 - 850 nm, filters and Optic Modules optimised for specific applications, and bespoke solutions are available
- Only for CLARIOstar, PHERAstar, VANTAstar, FLUOstar, LUMIstar Omega
- Microplate Stacker: optimises microplate handling and increases throughput by providing rapid loading, unloading, restacking, and continuous feeding for up to 50 microplates
- Only for CLARIOstar, PHERAstar, FLUOstar, LUMIstar, SPECTROstar Omega, NEPHELOstar
- LVis Plate: microplate for low-volume DNA, RNA and protein quantification. It includes 16 micro-drop (2 µL) wells, a cuvette slot and optional performance testing features
- Only for CLARIOstar, PHERAstar, VANTAstar, FLUOstar, SPECTROstar Omega, SPECTROstar Nano
- Evaluation Plate: validates the optical functionality of BMG LABTECH microplate readers for quality control and/or qualification (IQ/OQ) purposes
- Only for CLARIOstar, PHERAstar, VANTAstar, FLUOstar, , LUMIstar, SPECTROstar Omega, SPECTROstar Nano