BMG LABTECH - BMG Labtech - NEPHELOstar Plus

Manufactured by  BMG LABTECH
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The world's first and only laser-based microplate nephelometer. 

The world’s first and only laser-based microplate nephelometer was developed to meet high-throughput demands for fast compound solubility screens. The NEPHELOstar® Plus detects insoluble particles in liquid samples by measuring forward scattered light and can be used for turbidity measurements, drug solubility screening, protein binding kinetics, microbial growth, and petroleum process control.

The NEPHELOstar Plus is a microplate nephelometer with a high-intensity laser diode. It can be up to thirty times more sensitive than traditional transmission optical density readers that measure the reduction in direct light passing through a sample well. Thanks to its speed, flexibility and performance, the NEPHELOstar Plus allows more applications to be adapted to microplate-based laser nephelometry than ever before.

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Features of BMG Labtech - NEPHELOstar Plus
  • Adjustable laser intensity and beam diameter
  • Measurement in up to 384-well microplate format
  • Incubation up to 45°C or 60°C
  • Linear, orbital and double-orbital shaking
  • High-precision injectors with simultaneous reagent injection and detection
  • Microplate Stacker and robot compatible
General Specifications

There are no General Specifications available.

Additional Specifications

Detection Modes

Nephelometry (light scattering)

Measurement Modes

Endpoint and kinetic

Microplate Formats

Up to 384-well plates

Microplate Carrier

Robot compatible

Light Sources

Self-monitoring laser diode
Wavelength 635±10 nm
Stability <0.2% deviation
Lifetime 20,000 hours
Output: 1 mW
Selectable beam width: 1.5 to 3.5 mm
Selectable intensity 0-100%
Scattering angle: detects up to 80° full cone angle


Side window photodiode detector

Wavelength Selection

Wavelength 635±10 nm


Depends on particle size and liquid properties
Silica detection (particle size 0.5 to 10 µm) 800 nM

Dynamic Range: 5 decades
Maximum count rate (2,000,000 Relative Nephelometry Units (RNUs) per second)

Read Times

Depend on assay conditions and liquid surface stability
Shortest times possible: 16 s (96), 47 s (384)

Reagent Injection

Up to 2 built-in reagent injectors
Injection at measurement position (6 to 384-well)
Individual injection volumes for each well (3 to 500 µL)
Variable injection speed up to 420 µL / s
Up to four injection events per well
Reagent back flushing


Linear, orbital, and double-orbital with user-definable time and speed 

Purge Gas Vent 

System to inject an atmosphere or to pull a vacuum into the reader 


+4°C above ambient up to 45°C or 60°C

The upper heating plate of the incubation chamber operates at 0.5°C more than the lower plate. This prevents condensation build-up on the lid or sealer.  


Multi-user Reader Control and MARS Data Analysis Software included
FDA 21 CFR Part 11 compliant 


Width: 44 cm, depth: 48 cm, height: 32 cm; weight: 25 kg 

Optional Accessories 


Magazines for up to 50 plates - continuous loading feature 


Microplate incubator and shaker 


Please contact your local representative for upgrades including options such as detection modes, reagent injectors, etc. 


  • Atmospheric Control Unit (ACU): provides the ideal environment for cell-based assays by regulating O2 and CO2 gas levels in the microplate reader

  •                   Only for CLARIOstar, VANTAstar, FLUOstar, SPECTROstar Omega, LUMIstar Omega, NEPHELOstar Plus

  • Filters and Optic Modules: standard filters from 240 - 850 nm, filters and Optic Modules optimised for specific applications, and bespoke solutions are available

  •                   Only for CLARIOstar, PHERAstar, VANTAstar, FLUOstar, LUMIstar Omega

  • Microplate Stacker: optimises microplate handling and increases throughput by providing rapid loading, unloading, restacking, and continuous feeding for up to 50 microplates

  •                   Only for CLARIOstar, PHERAstar, FLUOstar, LUMIstar, SPECTROstar Omega, NEPHELOstar

  • LVis Plate: microplate for low-volume DNA, RNA and protein quantification. It includes 16 micro-drop (2 µL) wells, a cuvette slot and optional performance testing features

  •                    Only for CLARIOstar, PHERAstar, VANTAstar, FLUOstar, SPECTROstar Omega, SPECTROstar Nano

  • Evaluation Plate: validates the optical functionality of BMG LABTECH microplate readers for quality control and/or qualification (IQ/OQ) purposes

  •                   Only for CLARIOstar, PHERAstar, VANTAstar, FLUOstar, , LUMIstar, SPECTROstar Omega, SPECTROstar Nano

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