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  5. Waters - UPLC with On-line SPE Technology

Waters - UPLC with On-line SPE Technology

Manufactured by  Waters
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Streamlines drinking water analysis by providing analyte extraction, clean-up, concentration, separation, and detection in one turn-key solution.

The UPLC® with On-line SPE Technology streamlines the analysis of drinking water samples by providing analyte extraction, cleanup, concentration, separation, and detection in one turn-key solution.    
    
Automated sample handling, proprietary chromatographic media, ultra-sensitive optical & mass spectrometry detectors, and a database with complete LC/MS method information comprise an integrated on-line SPE/LC/MS/MS solution.    
    
Key benefits:    
        
    2. Throughput - Sample analysis and preparation times reduced from approximately three hours to as little as 15 minutes.    
    3. Flexibility - Functions as an on-line SPE system or a stand alone UPLC with multiple optical and mass spectrometer detection options.    
    4. Cost - The use of significantly smaller sample volumes can reduce shipping costs from remote locations.    
    5. Productivity - With a reduction in sample processing time, scientists can allocate more time to other laboratory tasks.    
    6. Quality - Ensures reproducible results by eliminating manual variability.    
    7. Applications - Detect endocrine disruptors, fungicides, herbicides, pesticides, personal care products, pharmaceuticals, soft drink additives, and veterinary drug residues.    
    
Drinking water sample preparation and analysis times. On-line SPE with UPLC/MS/MS versus Off-line SPE with LC/MS/MS.
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Features of UPLC with On-line SPE Technology
[u]Integrated System[/u]          The UPLC with On-line SPE Technology is a completely integrated solution that produces rapid, quality, consistent results. System components include:    
        
  • ACQUITY® Quaternary Solvent Manager - to load sample, wash, and recondition the extraction column    
  • ACQUITY Binary Solvent Manager - for elution and separation of the analytes    
  • Oasis® and XBridge™ Extraction Columns    
  • ACQUITY UPLC® Analytical Column    
  • Autosampler - holds up to 648 x 2 mL samples, or 36 x 20 mL samples    
  • Detector options - ACQUITY PDA, ACQUITY FLR, ACQUITY TQD, and Xevo™ TQ MS    
     [img]http://www.waters.com/webassets/cms/category/media/detail_page_images/on-line_SPE_config.jpg[/img]     [i]The UPLC with On-line SPE Technology is an innovative configuration of pumps and columns that allows for loading, washing, and separation to proceed in parallel, dramatically reducing analysis times.[/i]          [u]Sensitivity[/u]          Waters high performance optical and mass detectors enable the UPLC with On-line SPE Technology to detect and quantify trace contaminants.          [img]http://www.waters.com/webassets/cms/category/media/detail_page_images/On-line_spe_sensitivity.jpg[/img]     [i]Sensitivity of UPLC with On-line SPE and Xevo TQ Mass Spectrometer. Extracted ion chromatograms of pesticides at 10 ppt: carbendazim (192>160);atrazine (216.1>174), and metolachlor (284.3>252.1). Peak to peak signal-to-noise (with no prior processing) are shown for each compound.[/i]          [u]Data Management[/u]          The UPLC with On-line SPE Technology provides advanced data management capabilities to help improve analytical workflow:    
        
  • IntelliStart™ Technology - Automated mass spec setup and optimization ensures that users of all skill levels can quickly produce high quality results.    
  • Quanpedia™ Database - Rapidly create LC/MS/MS data acquisition and processing methods.    
  • TargetLynx™ Application Manager - Quantify and confirm contaminants while eliminating time-consuming, costly manual checks.    
  • MassLynx™ Mass Spectrometry Software - For comprehensive instrument control and data processing.    
          [u]Reproducibility & Linearity[/u]          Waters UPLC with On-line SPE Technology provides excellent data reproducibility and linearity.           [img]http://www.waters.com/webassets/cms/category/media/detail_page_images/On-line_spe_reproducibility.jpg[/img]          [i]Reproducibility of UPLC with On-line SPE and Xevo TQ Mass Spectrometer. Ten overlayed extracted ion chromatograms of carbendazim (192.05>160.05) at 20 ppt. Percentage RSD (on area) = 1.25%.[/i]          [img]http://www.waters.com/webassets/cms/category/media/detail_page_images/On-line_spe_linearity.jpg[/img]     [i]Linearity of UPLC with On-line SPE and ACQUITY TQ Detector. Cyanazine 12 point calibration from 10 to 5000 ppt.[/i]
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