Waters - UPLC with On-line SPE Technology
Streamlines drinking water analysis by providing analyte extraction, clean-up, concentration, separation, and detection in one turn-key solution.
Automated sample handling, proprietary chromatographic media, ultra-sensitive optical & mass spectrometry detectors, and a database with complete LC/MS method information comprise an integrated on-line SPE/LC/MS/MS solution.
Key benefits:
- Throughput - Sample analysis and preparation times reduced from approximately three hours to as little as 15 minutes.
- Flexibility - Functions as an on-line SPE system or a stand alone UPLC with multiple optical and mass spectrometer detection options.
- Cost - The use of significantly smaller sample volumes can reduce shipping costs from remote locations.
- Productivity - With a reduction in sample processing time, scientists can allocate more time to other laboratory tasks.
- Quality - Ensures reproducible results by eliminating manual variability.
- Applications - Detect endocrine disruptors, fungicides, herbicides, pesticides, personal care products, pharmaceuticals, soft drink additives, and veterinary drug residues.
Drinking water sample preparation and analysis times. On-line SPE with UPLC/MS/MS versus Off-line SPE with LC/MS/MS.
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Features of UPLC with On-line SPE Technology
Integrated System
The UPLC with On-line SPE Technology is a completely integrated solution that produces rapid, quality, consistent results. System components include:
- ACQUITY® Quaternary Solvent Manager - to load sample, wash, and recondition the extraction column
- ACQUITY Binary Solvent Manager - for elution and separation of the analytes
- Oasis® and XBridge™ Extraction Columns
- ACQUITY UPLC® Analytical Column
- Autosampler - holds up to 648 x 2 mL samples, or 36 x 20 mL samples
- Detector options - ACQUITY PDA, ACQUITY FLR, ACQUITY TQD, and Xevo™ TQ MS
The UPLC with On-line SPE Technology is an innovative configuration of pumps and columns that allows for loading, washing, and separation to proceed in parallel, dramatically reducing analysis times.
Sensitivity
Waters high performance optical and mass detectors enable the UPLC with On-line SPE Technology to detect and quantify trace contaminants.
Sensitivity of UPLC with On-line SPE and Xevo TQ Mass Spectrometer. Extracted ion chromatograms of pesticides at 10 ppt: carbendazim (192>160);atrazine (216.1>174), and metolachlor (284.3>252.1). Peak to peak signal-to-noise (with no prior processing) are shown for each compound.
Data Management
The UPLC with On-line SPE Technology provides advanced data management capabilities to help improve analytical workflow:
- IntelliStart™ Technology - Automated mass spec setup and optimization ensures that users of all skill levels can quickly produce high quality results.
- Quanpedia™ Database - Rapidly create LC/MS/MS data acquisition and processing methods.
- TargetLynx™ Application Manager - Quantify and confirm contaminants while eliminating time-consuming, costly manual checks.
- MassLynx™ Mass Spectrometry Software - For comprehensive instrument control and data processing.
Reproducibility & Linearity
Waters UPLC with On-line SPE Technology provides excellent data reproducibility and linearity.
Reproducibility of UPLC with On-line SPE and Xevo TQ Mass Spectrometer. Ten overlayed extracted ion chromatograms of carbendazim (192.05>160.05) at 20 ppt. Percentage RSD (on area) = 1.25%.
Linearity of UPLC with On-line SPE and ACQUITY TQ Detector. Cyanazine 12 point calibration from 10 to 5000 ppt.
General Specifications
There are no General Specifications available.