• Interactive diagnostics software for worry-free system and fluidics optimization and performance checks with IntelliStart™ Technology  
• 1 pg sensitivity with either ESI or APCI  
• 10,000 Da/sec scan speeds up to 2,000 Da for full compatibility with seconds-wide UPLC peaks  
• Simple upkeep and minimal bench space requirement  
• Dual orthogonal sampling ionization with ZSpray™ source  
• Rapid polarity switching and multi-mode ionization with simultaneous APCI and ESI for comprehensive compound analyses in a single injection, with ESCi® Technology  
• Multiple detection strategies available with supported Tunable UV (TUV), Photodiode Array (PDA), and Evaporative Light Scattering (ELS) optical detectors  
• Control and data acquisition with Empower™ or MassLynx™ Software  
• Optional APPI(Atmospheric Pressure PhotoIonization)  
• Optional application managers available  

Key Technology  

Rapid data acquisition capability:  

• To make the most of your ACQUITY UPLC® System, the SQ Detector operates at the highest data acquisition rates (utilizing fast scanning data acquisition, multi-mode ionization, and rapid polarity switching technologies)  

Automated instrument optimization and quantitative method development tools:  

• IntelliStart™ Software automates setting up the MS hardware (mass resolution, mass calibration, ion source optimization) and the process of developing compound-specific SIR data acquisition methods  
• QuanOptimize™, a sophisticated, optional software package, is available for comprehensive automation of the entire process of quantitation (method setup, data acquisition, data processing, and reporting)  

Versatile Range of robust ionization options:  

• Robust dual orthogonal API source (ZSpray™): Maximizes source longevity, protects against dirty samples, and allows easy removal and cleaning of source elements without breaking vacuum  
• Ionization options include: electrospray and multi-mode ionization capability (standard), atmospheric chemical ionization, and dual-mode atmospheric pressure photo-ionization / atmospheric chemical ionization interface  

Comprehensive software control and applications:  

• MassLynx™ MS Software or Empower™ 2 CDS Software solutions suit your analytical requirements  
• Optional OpenLynx™ Application Manager provides walk-up access to non-expert users for UPLC/MS applications  

Intelligent Services Delivery Platform  

• Connections INSIGHT® intelligent services provides on-demand, remote diagnostics and online help for your LC/MS system.  

Linearity and Precision are Superb  

  

Broad quantitative linearity is demonstrated over a range of 1 pg to 2,000 pg on-column for reserpine.  

  

High quantitative reproducibility is shown for 10 pg reserpine injections on-column (n=20)  

Good Quality MS Information     

The ACQUITY® SQD provides more quality information about your samples in less time. The SQ Detector delivers 10,000 Da/sec scan speeds and interscan delays as low as 20 msec to accommodate the narrowest UPLC peaks.  

IntelliStart Technology  

IntelliStart™ Technology automates system setup so that non-expert users can acquire data with confidence that the system is operating optimally.   

An integrated system of fluidics, electronics, and software continually monitors system performance. Through a series of diagnostic checks, the MS detector can report when it is ready for use. Any failures trigger a red-light system status, which warns that action may be required before analysis can proceed.  

IntelliStart Technology:  

• Resolves system alerts  
• Autotunes and calibrates the system, optimized for your analysis  
• Automatically generates SIR methods with ease using integrated fluidics  
• Reports on your LC/MS system performance