SYNAPT™ MS Systems combine a unique range of key innovative technologies that drive enhanced productivity in a wide variety of applications:    

    
• ACQUITY UPLC® – enhances MS-based studies with the highest chromatographic resolution, speed, and sensitivity.    
• SYNAPT MS Systems – generate high quality Exact Mass measured data and, together with MSE, are the ultimate complement to UPLC® separations.    
• MassLynx™ Informatics – Application Managers combine the full power of Exact Mass data with Chemically Intelligent technologies (built-in understanding of chemistry) that enable you to extract more meaningful information, increase confidence in results, and to make better decisions.    

     Enabling Technology          SYNAPT™ MS Systems provide you with a flexible research platform for a wide range of applications based on either Exact Mass UPLC®/API/MS/MS or Exact Mass MALDI/MS/MS.          SYNAPT MS is a next generation platform that can be configured to meet a wide range of complex analytical challenges via:    

    
• Next generation tandem mass spectrometry platform– fully upgradeable on site to incorporate SYNAPT HDMS™ functionality, extending your capabilities to make new discoveries possible.    
• UPLC/MSE – Avoids under sampling of complex mixtures for more comprehensive, confident, and rigorous profiling of proteins, metabolites, and impurities.    
• Triwave™ Technology – dual-stage collision cell configuration provides optimized MS/MS for comprehensive structural characterization.    
• Exchangeable vacuum MALDI source – Solid state 200 Hz lazer provides rapid analysis in protein profiling and tissue imaging studies.    
• Optimized precursor ion selection – 4, 8, and 32 kDa quadrupole options provide high selectivity for MS/MS analysis of small molecules to protein complexes.    
• Source options – LockSpray™, NanoLockSpray™, IonSABRE™, APCI, ESCi®, and APPI provide comprehensive detection of chemically diverse compounds.    

     Atmospheric Solids Analysis Probe          The AtmosphericSolids Analysis Probe (ASAP) is a powerful tool for the rapid direct analysis of volatile and semi-volatile, solid and liquid samples using atmospheric pressure ionization.          The ASAP technique utilizes the heated nitrogen desolvation gas to vaporize the sample and a corona discharge for sample ionization. This allows low polarity compounds not amenable to ESI, APcI, and APPI to be ionized with a high degree of sensitivity. Furthermore complex mixtures can be analyzed without the need for any sample preparation.          The AtmosphericSolids Analysis Probe is readily fitted to a standard API source by replacing either the ESI or APcI probe assembly. A corona discharge pin also requires fitting. The close proximity of the sample, when loaded onto a glass capillary tube, to the point of ionization and the MS inlet, improves sensitivity whilst also ensuring safety due to the enclosed source housing.          Instruments are operated in combined Electrospray/APcI mode (ESCi®). This provides for the acquisition of both analyte data in APcI mode and reference data in electrospray mode, enabling exact mass measurements to be produced.          The probe is designed to have both fixed & removable sections to allow rapid sample introduction without removal of the complete assembly ensuring stable source conditions.          Upgradeability          Future proof your laboratory. SYNAPT™ MS Systems are fully upgradeable.          The true power of a scientific breakthrough is its impact on the world outside the laboratory walls. For laboratories to rise to the world’s greatest challenges, scientists must think beyond the science performed in organizations today.          SYNAPT MS systems are next generation quadrupole oa-TOF platforms which can be transformed on-site to incorporate full High Definition MS functionality, allowing you to analyze samples that are differentiated by size, shape and charge as well as mass to deliver increased specificity and sample definition beyond that achievable by conventional MS.          [img]http://www.waters.com/webassets/cms/category/media/content_box_images/SYNAPT_MS_detail_2.jpg[/img]          SYNAPT HDMS Systems - HDMS Mode and TOF Mode: Access unique benefits of high-efficiency IMS and tandem MS to carry out conformational studies, reduce spectral complexity/background interferences, and retrieve more information from fragmentation studies.          MALDI and API: Provide the ultimate flexibility in MS mode and HDMS mode for high-efficiency IMS separation of ions from MALDI and API.          SYNAPT MS Systems: Access to new levels of productivity with application specific system solutions.