This product is Discontinued

Waters - Xevo TQ MS

Manufactured by Waters

Xevo™ TQ from Waters is designed for quantitative UPLC/MS/MS applications, so you can confidently quantify and...

Xevo™ TQ from Waters is designed for quantitative UPLC/MS/MS applications, so you can confidently quantify and confirm trace components in the most complex of samples. What's more, you can do this with unparalleled ease, speed, and accuracy. Xevo TQ features ScanWave™ collision cell technology to provide enhanced spectral LC/MS/MS data acquisition capabilities. Unlike conventional tandem quadrupole mass spectrometers, the Xevo TQ is designed to provide not only the very best quantitative data, but also superior spectral MS/MS information. You benefit from more versatility in a single instrument platform, which is adaptable to a wide variety of different UPLC/MS/MS applications both quantitative and qualitative: bioanalysis, ADME screening, food safety, environmental monitoring, forensic, and more. Features:

Engineered Simplicity™ - the combination of highest performance with system versatility and simplicity of operation
ScanWave - innovative technology that provides rapid, high quality, UPLC®-compatible, MS/MS data acquisition
RADAR - an information rich acquisition approach that allows you to colllect highly specific quantitative data for target compounds while providing the ability to visualize all other components
Versatility - an extensive range of ionization capabilities to service the broadest range of applications
Simplicity of operation - guarantees maximum system performance that is accessible to the broadest range of users

Active Questions & AnswersAsk a Question

Need Equipment Support?

Request Support

Manuals & DocumentsFeaturesSpecifications

Documents & ManualsView All Documents

Features of Xevo TQ MS

ScanWave™ enables rapid MRM acquisition for targeted quantification and enhanced sensitivity MS/MS full scan data collection for structural confirmation
RADAR™ - an information-rich acquisition approach that allows you to collect highly specific quantitative data for target compounds while providing the ability to visualize all other components in sample matrices
Ion Source Options - offers the most extensive range of interface capabilities to service the broadest range of applications

ScanWave With its unique collision cell, Xevo TQ enables you to better address your analytical needs with the option to operate in a new ScanWave enhanced product ion scanning mode. In this mode, ions are accumulated and then separated according to their mass-to-charge ratio (m/z). Synchronizing the release of these ions with the scanning of the second quadrupole mass analyzer significantly enhances the signal intensity of full scan product ion spectra. Simply put, this enables you to more easily confirm the identities and structures of your analytes of interest. [img]http://www.waters.com/webassets/cms/category/media/detail_page_images/XevoTQ_detail4_scanwave.jpg[/img] [i]Xevo TQ is capable of the highest MRM data acquisition rates without significant losses in signal. This ensures the very best MRM quantification data for your demanding, high speed, and high resolution UPLC/MS/MS assays.[/i] RADAR You no longer have to accept the complications and uncertainty associated with matrix effects. When performing targeted quantification, RADAR allows you to see the whole picture, and have total confidence. In RADAR mode, you can monitor for matrix interferences, metabolites, impurities, and degradants in your sample while accurately quantifying your target compounds. [img]http://www.waters.com/webassets/cms/category/media/detail_page_images/XevoTQ_detail1_radar.jpg[/img] [i]With RADAR you can collect data in both multiple reaction monitoring (MRM) and full scan spectral acquisition modes at the same time. In addition, RADAR mode acquires all detectable ions in both positive and negative full scan MS, arming you with a depth of knowledge about your sample not previously possible from a traditional quantitative assay. RADAR is only possible because of the ability to rapidly alternate between MS, MS/MS, positive, and negative ion modes without compromising performance in any mode.[/i] Ion Source Options The universal ion source architecture of Xevo TQ allows the widest range of ionization techniques to be utilized as well as the very latest innovations in ionization technologies. So you'll have limitless choice in experimental options. When you need options and time is critical, the ion sources are quickly interchangeable and ready to use within minutes. [img]http://www.labwrench.com/core/images/articles/images/ions.JPG[/img]

General Specifications

Depth	35.6 in
Height	27.8 in
Mass Range	2 to 2048 m/z
Width	24 in
Scan Speed	10000 amu/sec
Mass Spectrometer Type	Quadrupole Mass Analyzer

Additional Specifications

API sources and ionization modes: High performance ZSpray dual-orthogonal API sources:
1. Multi mode source - ESI/APCI/ESCi (standard)
NB - Dedicated APCI requires an additional prove (optional)
2. Dual mode APPI/APCI source (optional)
3. Nano-flow ESI source (optional)
4. Atmospheric pressure solids analysis prove - ASAP (optional)
5. Atmospheric pressure gas chromatography ion source - APGC (optional)
Optimized gas flow dynamics for efficient ESI desolvation (supporting LC flow rates up to 2 mL/min)
Tool-free source exchange
Vacuum isolation valve
Tool free access to customer serviceable elements
Plug and play probes
De-clustering cone gas
Software control of gas flow and heating elements
Ion source transfer optics: High efficiency hexapole ion guide
Mass analyser: Two high resolution quadrupole analyzers (MS1/MS2), plus pre-filters to maximize resolution and transmission while preventing contamination of the main analyzers
Collision cell: T-Wave enabled for optimal MS/MS performance at high data acquisition rates; ScanWave enabled for enhanced MS/MS spectral performance (product ion scanning); Software programmable gas control
Detector: Low noise, off axis, long life photomultiplier detector; digital dynamic range up to 4x10^6
Vacuum system: Two air-cooled vacuum turbomolecular pumps evacuating the source and analyzer; one rotary backing pump
Regulatory approvals: IVD, CE, and NRTL

[u]Performance[/u]
Acquisition modes: Full scan MS
Product ion scan (ScanWave enhanced)
Precursor ion scan
Constant neutral loss
Selected ion recording (SIR)
Multiple reaction monitoring (MRM)
Survey scan modes: Full scan MS triggered product ion scan
Precursor ion scan triggered product ion scan
Constant neutral loss triggered product ion scan
Quan Qual modes: MRM triggered ScanWave enhanced product ion spectral acquisition
Examples of achievable acquisition rates:
10 scans per second (m/z 100 to 1000)
20 scans per second (m/z 50 to 500)
Mass stability: Mass drift is less than 0.1 amu over a 24 hour period
Linearity of response: The linearity of response relative to sample concentration, for a specific compound, is five orders of magnitude from the limit of detection
Polarity switching time: 20 ms to switch between positive and negative ion modes
MS to MS/MS switching time: 5 ms
ESCi mode switching time: 20 ms to switch between ESI and APCI
MRM acquisition rate: Maximum acquisition rate of 167 MRM data points per second;
Minimum dwell time of 3 ms per MRM channel'
Minimum inter-channel delay of 3 ms
Inter-channel cross talk: The inter-channel cross talk between two MRM transitions, acquired using an MRM dwell time of 10 ms and an inter-channel delay time of 10 ms, will be less than 0.02%
Number of MRM channels: Up to 16,384 MRM channels (512 functions, 32 channels per function) can be monitored in a single acquisition; up to 1024 MRM channels when operating in GLP/secure modes (32 functions, 32 channels per function)
Mass resolution: Automatically adjusted (IntelliStart) to desired resolution; the valley between the 2034.63 Da and 2035.63 Da peaks is 156 m/z greater than 500:1
MRM sensitivity (ESI-): A 1 pg on column injection of chloramphenicol, with a mobile phase flow rate of 0.8 mL/min, will give a chromatographic signal-to-noise for the transition 312 > 152 m/z greater than 1000:1
MRM sensitivity (APCI+): A 10 pg on column injection of 17-alpha-hydroxyprogesterone, with a mobile phase flow rate of 0.8 mL/min, will give a chromatographic signal-to-noise for the transition 331 > 109 m/z greater than 100:1
MRM signal-to-noise definition; Signal is defined as the height of the chromatographic peak of interest and noise is defined as the RMS of a continuous section of the mass chromatogram