Features of Xevo TQ-S

General Specifications

Additional Specifications

System Hardware Specifications:              
API sources and ionization modes: High performance ZSpray dual-orthogonal API sources:              
1. Multi-mode source - ESI/APCI/ESCi (standard)              
NB - Dedicated APCI requires an additional probe (optional)              
2. APCI IonSABRE II probe (optional)              
3. Dual model APPI/APCI source (optional)              
4. nanoFlow ESI source (optional)              
5. ASAP (optional)              
6. APGC ion source (optional)              
7. TRIZAIC ion source (optional)              
Tool-free access to user serviceable elements              
Plug-and-play probes              
De-clustering cone gas              
Software control of gas flows and heating elements              
Ion source transfer optics: StepWave ion transfer optics delivering class leading UPLC/MS/MS sensitivity. The uniqe off-axis design dramatically increases the efficiency of ion transfer from the ion source to the quadrupole MS analyzer at the same time as actively eliminating undesirable neutral contaminants.              
Mass analyzer: Two high-resolution, high-stability quadrupole analyzers (MS1/MS2), plus pre-filters to maximize resolution and transmission while preventing contamination of the main analyzers.              
Collision cell: T-Wave enabled for optimal MS/MS performance at high data acquisition rates; ScanWave enabled for enhanced MS/MS spectral performance (product ion scanning); Software programmable gas control              
Detector: Low-noise, off-acis, long-life photomultiplier detector              
Digital dynamic range of 4x10^6              
Vacuum system: Three air-cooled turbomolecular vacuum pumps; Two vacuum backing pumps              
Regulatory approvals: CE and NRTL              
              
Performance Specifications:              
Acquisition modes:              
Full scan MS              
Product ion scan (ScanWave enhanced)              
Precursor ion scan              
Constant neutral loss scan              
Selected ion recording (SIR)              
Multiple reaction monitoring (MRM)              
Survey scan modes: Full scan MS data acts as an automatic trigger for the collection of ScanWave-enhanced product ion spectra              
Precursor ion scan data acts as an automatic trigger for the collection of Scan-Wave-enhanced product ion spectra              
Constant neutral scan data acts as an automatic trigger for the collection of ScanWave-enhanced product ion spectra              
Product ion confirmation (PIC) mode: MRM data acts as an automatic trigger for the collection of ScanWave-enhanced product ion spectra              
RADAR: An information rich acquisition approach that allows you to collect highly specific quantitative data for target compounds while providing the ability to visualize all other components              
Examples of achievable acquisition rates:              
10 scans per second (m/z 50 to 1000)              
20 scans per second (m/z 50 to 500)              
Mass stability: Mass assignment will be within +/- 0.05 Da over a 24 hours period (the instrument must be operated in conformance with the laboratory environmental guidelines given in the Xevo TQ-S site perparation guide)              
Linearity of response: The linearity of response relative to sample concentration, for a specified compound, is five orders of magnitude from the limit of detection              
Polarity switching time: 20 ms to switch between positive and negative ion modes              
MS to MS/MS switching time: 3 ms              
ESCi mode switching time: 20 ms to switch between ESI and APCI              
MRM acquisition rate: Maximum acquisition rate of 250 MRM data points per second;              
Minimum dwell time of 1 ms per MRM channel;              
Minimum inter-channel delay of 3 ms              
Inter-channel cross talk: The inter-channel cross talk between two MRM transitions, acquired using an MRM dwell time of 1 ms and an inter-channel delay time of 3 ms, is less than 0.01%              
Number of MRM channels: Up to 16,384 MRM channels (512 functions, 32 channels per function) can be monitored in a single acquisition; up to 8,000 MRM channels when operating in GLP/secure mode (250 functions, 32 channels per function)              
Mass resolution: Automatically adjusted (IntelliStart) to desired resolution;              
The valley between the m/z 2034.63 and m/z 2035.63 peaks is 195)              
MRM sensitivity (ESI-) A 1 pg on-column injection of chloramphenicol will give a chromatographic signal-to-noise greater than 3000:1 (LC mobile phase flow rate of 0.8 mL/min, MRM transition m/z 321 >152)              
MRM sensitivity (APCI+): A 1 pg on-column injection of 17-alpha-hydroxyprogesterone will give a chromatographic signal-to-noise greater than 100:1 (LC mobile phase flow rate of 0.8 mL/min, MRM transition m/z 331>109)              
MRM signal-to-noise defition: Signal is defined as the height of the chromatographic peak of interest and noise is defined as the RMS of a continuous section of the mass chromatogram