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Waters - Quattro Premier XE

Manufactured by  Waters
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Developed for your most demanding LC/MS/MS quantitative applications, the Quattro Premier™ XE tandem quadrupole...

Developed for your most demanding LC/MS/MS quantitative applications, the Quattro Premier™ XE tandem quadrupole mass spectrometer features the highest levels of sensitivity, selectivity, robustness, speed and accuracy.     To maximize the analytical advantages of your ACQUITY UPLC® System, the Quattro Premier XE operates at the highest data acquisition rates. Together, the ACQUITY UPLC® System and the Quattro Premier XE give you industry-leading analytical detection limits, resolution and sample throughput for all of your quantitative applications: Bioanalysis, ADME screening, food safety, environmental monitoring, clinical and more.     Features:  
  1. The best in accuracy and reproducibility of chromatographic peak area measurement  
  2. Robust ZSpray™ atmospheric pressure ionization interface  
  3. Versatile range of ionization options, including multi-mode ionization capability in a single run  
  4. Optional QuanOptimize™ automated instrument optimization and quantitative method development tools  
  5. TargetLynx™ dedicated application managers for your specialized analytical requirements  
  6. Small footprint that sits easily on your laboratory benchtop  
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Features of Quattro Premier XE

Rapid Data Acquisition Capability    

To make the most of your ACQUITY UPLC® System, the Quattro Premier™ XE operates at the highest data acquisition rates, utilizing T-Wave™ collision cell, multi-mode ionization and rapid polarity switching technologies.    

Automated Instrument Optimization and Quantitative Method Development Tools    

Software automates setting up the MS hardware (mass resolution, mass calibration, ion source optimization).    

QuanOptimize™, a sophisticated, optional software package, is available to automate the entire quantitation process (method set-up, data acquisition, data processing, and reporting).    

Versatile Range of Robust Ionization Options    

Robust dual orthogonal API source (ZSpray™) maximizes source longevity, protects against dirty samples, and allows easy removal and cleaning of source elements without breaking vacuum.    

Ionization options include electrospray and multi-mode ionization capability (standard), atmospheric chemical ionization, and dual-mode atmospheric pressure photo-ionization / atmospheric chemical ionization interface.    

Enhanced Sensitivity    

Incorporates industry-leading dynolite photomultiplier ion detection technology (WHISPER™ Detector) to reduce detector noise for both positive and negative ion modes, and improve sensitivity in negative ion mode.    

The maintenance-free photomultiplier detector is enclosed in its own vacuum envelope.    

Comprehensive Ionization Capabilities    

When you need to incorporate mass spectrometry into your laboratory, you want your instrumentation to be as versatile as possible to meet your ongoing analytical needs.    


Waters’ portfolio of MS technologies provides a broad range of atmospheric pressure ionization (API) sources to allow your laboratory to meet its productivity requirements:    

  • Electrospray (ESI) Probe: The most widely used API technique for sensitive, general analysis of polar and ionic compounds    
  • Atmospheric Pressure Chemical Ionization (APCI) Probe: Ionization capabilities for less polar and neutral chemical species    
  • IonSABRE™ APCI: Excellent sensitivity for less polar and nonpolar analytes, especially at higher liquid flow rates    
  • ESCi® Multi-Mode Ionization: Combines ESI and APCI in the same analysis    
  • APPI/APCI Dual Ionization: Provides APCI in simultaneous operation with photoionization (PI)    

Built on the ZSpray™ API Interface, each of these ionization sources provides the robust performance you expect of your mass spectrometer.    

Rapid Data Acquisition Capability    

Accurate quantitation of typical of UPLC® (2-3 s) narrow peak widths demands fast acquisition speeds for sufficient data points per peak (15-20).    

T-Wave™ (Traveling Wave™) collision cell technology minimizes source-to-detector ion transit times for high-speed data acquisition. Unlike some collision cell designs, the T-Wave collision cell ensures that signal intensity does not fall as acquisition speed increases.    

In this example, the chromatographic signal intensity is maintained as MRM acquisition dwell time is reduced from 200 ms (5 data points per second) to 5 ms (100 data points per second).    

     Rapid positive to negative ion mode switching (in only 20 ms) also enables simultaneous analysis of acidic and basic compounds in a single analytical run. Scientists can take full advantage of the speed of UPLC saving valuable analytical time.    

Why Tandem Quadrupole MS?    

Tandem quadrupole mass spectrometers are versatile instruments that can perform a wide variety of experiments:    

  • Full scan for mass confirmation    
  • Single ion recording for selected ion monitoring    
  • Product ion scan for structural elucidation    
  • Precursor scan for class-specific screening using common fragments    
  • Constant neutral loss for class-specific screening using common losses    
  • Multiple reaction monitoring for selective, trace level quantitation    


The use of two mass analysers provides improved data quality for a wide range of applications:    

  • High selectivity to reduce or eliminate matrix interferences    
  • High sensitivity for trace levels - low reporting limits    
  • Quantitative accuracy for reproducibility, stability and dynamic range, and accurate quantitation of targets at low levels in matrix    
  • Robustness for complex sample matrices, reduced sample clean-up
General Specifications

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