Ion Mobility Separation and Measurement    

• Isolate and identify isobaric ions invisible by traditional mass spectrometry    
• Separate ions of interest from matrix peaks    
• Separate ions by size, shape, charge, and mass    
• Ion accumulation prior to mobility separation means no loss in sensitivity    
• Dedicated DriftScope™ Software allows you to visualize and manipulate four dimensions of information intuitively    

Enhanced Fragmentation Capabilities    

• Generate first- and second-generation product ions from a single experiment for detailed structural information    
• Accurate precursor selection allows you to generate sequenceable data from individual ions    
• Near-point lockmass correction (in MALDI mode) and LockSpray™ (in API mode) dependably give exact mass data without ion suppression    

Interchangeable Modes of Operation    

• Vacuum MALDI source incorporates a 200 Hz solid state UV laser    
• Real-time digital display of sample during analysis    
• Perform MALDI imaging experiments directly from glass microscope slides    

Triwave Technology    

Triwave™ Technology is the enabling technology behind the SYNAPT™ HDMS™ System. It uses three T-Wave™* ion guides that trap ions, separate them by their ion mobility, and transfer them to the orthogonal acceleration time-of-flight analyzer for high resolution mass analysis. The trap and transfer regions can also be used for fragmentation analyses.    

Triwave’s innovative configuration overcomes the major performance drawbacks of conventional ion mobility spectrometry (IMS) by ensuring that IMS does not compromise sensitivity.    

     Triwave Technology, the enabling technology behind Synapt HDMS.     *The Traveling wave device described here is similar to that described by Kirchner in US Patent 5,206,506; 1993.    

Reduced Sample Complexity    

The SYNAPT™ High Definition Mass Spectrometry™ System provides a unique way to increase the information content for a wide variety of applications. DriftScope™ Software eliminates common interferences from an analysis, providing access to lower-level components:    

• Separation of interferences    
• Charge state separation    
• Increased information content    

This example shows the spectra from the analysis of released glycans from IgG using a MALDI SYNAPT HDMS™ System.    

     The effect of using ion mobility to remove background ions.    

Atmospheric Solids Analysis Probe    

The Atmospheric Solids Analysis Probe (ASAP) is a powerful tool for the rapid direct analysis of volatile and semi-volatile, solid and liquid samples using atmospheric pressure ionization.    

The ASAP technique utilizes the heated nitrogen desolvation gas to vaporize the sample and a corona discharge for sample ionization. This allows low polarity compounds not amenable to ESI, APcI, and APPI to be ionized with a high degree of sensitivity. Furthermore complex mixtures can be analyzed without the need for any sample preparation.    

The AtmosphericSolids Analysis Probe is readily fitted to a standard API source by replacing either the ESI or APcI probe assembly. A corona discharge pin also requires fitting. The close proximity of the sample, when loaded onto a glass capillary tube, to the point of ionization and the MS inlet, improves sensitivity whilst also ensuring safety due to the enclosed source housing.    

Instruments are operated in combined Electrospray/APcI mode (ESCi®). This provides for the acquisition of both analyte data in APcI mode and reference data in electrospray mode, enabling exact mass measurements to be produced.    

The probe is designed to have both fixed & removable sections to allow rapid sample introduction without removal of the complete assembly ensuring stable source conditions.