Waters - Semi-Preparative to Preparative-Scale HPLC Purification

Manufactured by  Waters
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Perform both analytical and automated preparative chromatography on a single, high-throughput HPLC platform. Purify microgram to multigram quantities.

Preparative-scale chromatography plays a critical role in applications where compounds must be synthesized, identified, isolated, purified, characterized, screened, and tested. Waters AutoPurification Systems offer scalable prep configurations, whether you want the specificity of mass-directed purification or inclusiveness of a UV system. The AutoPurification HPLC/MS System provides you with the flexibility of using high-throughput parallel runs for selective mass-directed fraction collection from hundreds of samples. With the AutoPurification HPLC System, run samples around the clock with unprecedented versatility and consistency.

  • Take the complexity out of purification with our versatile solutions that are capable of purifying micrograms to multigram quantities.
  • Automatically process hundreds of samples - or just a few.
  • Robust and reliable systems improve your ability to manage increasing workload demands, including unattended instrument operation.
  • Flexible configurations enable easy scale-up from analytical to preparative chromatography.
  • FractionLynx Application Manager automates the collection of detected fractions, tracks samples and fractions, and then presents the data in an easy-to-view format. The software can trigger collection using a variety of detector signals including UV/Visible, Evaporative Light Scattering (ELS), MS, and analog.
  • User-friendly console and software features help you manage solvents and samples, whether you do manual or automated injections.
  • Proprietary Optimum Bed Density (OBD) Column design offers the highest sample loading and unmatched column stability.
  • Easy-to-upgrade systems help you bring the latest technologies to your lab.
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Features of Semi-Preparative to Preparative-Scale HPLC Purification

When fraction collection is based on UV absorbance, multiple fractions may result, requiring further analysis to determine the fraction of interest.

With the AutoPurification HPLC System, run samples around the clock with unprecedented versatility and consistency. The System Fluidics Organizer enables you to easily manage column selection and column regeneration.

The AutoPurification HPLC System includes:

  • 2767 Sample Manager
  • 2545 Binary Gradient Module
  • System Fluidics Organizer
  • 2489 UV/Vis Detector
  • MassLynx Software with the FractionLynx Application Manager

Open Access Purification

Whether your company manages preparative LC in a centralized lab or provides purification capabilities in an open access environment, Waters' easy-to-use systems and software allow samples to be run with unattended system operation. This improves productivity by enabling chemists to focus on their results rather than on the instrument. Waters systems and software make purification easier to manage:

  • With Open Access software, chemists can walk up to a system, enter their sample, and have results delivered to their desktop, while an administrator monitors the system and manages instrument access
  • Fraction collection software provides full-cycle automation, from evaluation and setting collection thresholds, to purification, to fraction analysis
  • Unique method filtering software enables the user to quickly choose a method from the existing library of methods
  • Automatically generate gradients without having to manually buffer solvent concentration, and build column cleanup and system flushing into your method
  • Solvent monitoring system enables you to use multiple solvent reservoirs, with automated warning responses about instrument status, with intelligent shut-down available
  • Remote system status monitor tracks the sample queue, instrument, and solvent and waste container status online
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