Thermo Scientific - LTQ XL™ Linear Ion Trap Mass Spectrometer
Obtain more structural information for proteomics and metabolism applications. The Thermo Scientific™ LTQ...
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Features of LTQ XL™ Linear Ion Trap Mass Spectrometer
The LTQ XL ion trap MS extends the legendary MSn performance of the LTQ ion trap, incorporating more techniques to generate structural information through innovations in Thermo Scientific ion trap technology.
- Unparalleled sensitivity and unmatched MSn spectral quality
- Pulsed Q dissociation (PQD) for generating more fragments and extending the low mass range
- Electron transfer dissociation (ETD) option provides sequence information not available from conventional methods
- High-resolution isolation (HRI) enables isolation of isobaric mass peaks for cleaner MSn spectra
- Ultra-fast polarity switching for high sensitivity analysis of unknowns
- Automated data-dependent neutral loss for PTM and biotransformation analyses
- Excellent charge state determinations with Ultra ZoomScan™
- Upgradeable to Thermo Scientific™ LTQ Orbitrap XL high-resolution, accurate-mass technology
The LTQ XL supplies outstanding sensitivity and abundant structural information for:
- Protein identification and quantitative differential expression analysis
- Biomarker studies and PTM identification
- Metabolite identification and quantification
- Tissue imaging
- High-speed LC methods
For Research Use Only. Not for use in diagnostic procedures.
General Specifications
Depth | 59 cm |
Height | 56 cm |
Width | 79 cm |
Weight | 120 kg |
Mass Spectrometer Type | Ion-Trap Mass Analyzer |
Additional Specifications
Hardware Features
Ion Max™ API Source
- Enhanced sensitivity and ruggedness
- Sweep Gas™ reduces chemical noise
- 60° interchangeable ion probe orientation
- Removable metal ion capillary tube provides vent-free maintenance
Transfer Ion Optics
- Advanced ion guides
- High stability and ion transmission efficiency
2D Linear Quadrupole Ion Trap Mass Spectrometer
- Optimized analyzer dimensions
- Regulated helium flow for stable performance
- Automatic system calibration
- High-efficiency radial ion ejection
Vacuum System
- Differentially-pumped vacuum system
to 10-5 Torr
- Split-flow turbomolecular pump controlling vacuum in three regions
- Dual rotary vacuum pump configuration
- High-vacuum aluminum analyzer chamber
Detection System
- Patented dual conversion dynode detector
- Two off-axis continuous dynode electron multipliers with extended dynamic range
- Digital electronic noise discrimination
Integrated Divert Valve
- Fully-automated data system control enables user to divert the solvent front, gradient end point and any other portion of the HPLC run to waste
- User-definable default state of the valve, either to waste or to source
Integrated Syringe Pump
- Syringe Pump allows automated infusion under data system control
Options
- ESI probe compatible with liquid flow rates of <1 µL/min to 1 mL/min, without splitting
- APCI source compatible with liquid flow rates of 50 µL/min to 2 mL/min, without splitting
- APCI/APPI source compatible with liquid flow rates of 50 µL/min to 2 mL/min, without splitting
- Electron Transfer Dissociation (ETD) enabled
- vMALDI™ ion source combines the speed of MALDI with the sensitivity and selectivity of MS/MS
- Nanospray source supports static packed tip and dynamic nanospray experiments, compatible with liquid flow rates of 50 nL/min* to 2 µL/min
- Metal needle option for high- and low-flow analyses
*Lower limit is dependent on gauge of needle used
System Specifications
MS/MS Sensitivity Electrospray Ionization (ESI) A loop injection of 2 µL of a 125 fg/µL solution of reserpine (250 femtograms total sample) at a flow of 400 µL/min of 50% isopropyl alcohol/50% water will produce a minimum signal-to-noise ratio of 100:1, for the transition of the isolated protonated molecular ion at m/z 609 to the largest two product ions, 397 and 448, when the mass spectrometer is operated at unit resolution in the full-scan MS/MS mode, scanning the product ion spectrum from m/z 165 615.
Atmospheric Pressure Chemical Ionization (APCI) A loop injection of 2 µL of a 125 fg/µL solution of reserpine (250 femtograms total sample) at a flow of 400 µL/min of 50% isopropyl alcohol/50% water will produce a minimum signal-tonoise ratio of 100:1, for the transition of the isolated protonated molecular ion at m/z 609 to the largest two product ions, 397 and 448, when the mass spectrometer is operated at unit resolution in the fullscan MS/MS mode, scanning the product ion spectrum from m/z 165 615.
MSn Sensitivity Electrospray Ionization (ESI) - A loop injection of 2 µL of a 125 fg/µL solution of reserpine (250 femtograms total sample) at a flow of 400 µL/min of 50%
isopropanol/50% water will produce a minimum signal-to-noise ratio of 25:1, for the transition of the unit isolated protonated molecular ion at m/z 609 to the product ion at m/z 397 which is further fragmented to the product ion at m/z 365, when the mass
spectrometer is operated at unit resolution in the full-scan MS/MS mode, scanning the
product ion spectrum from m/z 165-615.
Installation Requirements
Power
- One 230 Vac ±10.0%, 15 Amps, 50/60 Hz, single phase, with earth ground dedicated
to the instrument
- 120 or 230 Vac single phase, with earth ground for the data system
Gas
- One high-purity (99% pure, flow rate 15 L/min) nitrogen gas supply for the API source
- One ultra high-purity helium gas supply (99.998% pure) with less than 1 ppm each of water, oxygen, and total hydrocarbons for the mass analyzer
Environment
- System averages 2300 W (8000 Btu/h) output when considering air conditioning needs
- Operating environment must be 15-27 °C (59-80 °F) and relative humidity must be 40-80% with no condensation
- Optimum operating temperature is 18-21 °C (65-70 °F)
Weight: Two roughing pumps: 38.6 kg each
Performance Specifications
Mass Range
m/z 15 200
m/z 50 2000
m/z 200 4000
Resolution
Down to 0.05 FWHM (full width half maximum) with Ultra ZoomScan
Polarity Switching
100 msec between positive and negative
MS Scan Power
MSn, for n = 1 through 15
Contact Closure
Start In/Out
Start Out is programmable
Analog Inputs
One (1) analog Input (0-1 V)
One (1) analog Input (0-10 V)