This product is Discontinued

Molecular Devices - CellKey System

Manufactured by  Molecular Devices
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Label-free, real-time analysis of cell surface receptor activity in a single-assay format.

The CellKey™ System is a revolutionary, functional cell-based assay platform enabling label-free, real-time analysis of cell surface receptor activity in a single-assay format.  
  
The system's underlying technology is Cellular Dieletric Spectroscopy (CDS) — an impedance based measurement system that eliminates the need for tags, dyes, or specialized reagents. Learn more about CDS.  
  
The system was designed to meet the needs of drug discovery scientists-- from target identification and validation through lead optimization. It is sensitive enough to consistently monitor ligand-mediated activation of endogenous receptors expressed in adherent or suspension cell lines and primary cells. The benefit of this is the ability to generate more physiologically relevant data than obtained when using genetically and chemically manipulated cells.  
  
The CellKey™ platform package is a fully integrated solution comprised of the instrument with on-board temperature control and fluidics, and an extensive software suite to manage the information-rich, real-time kinetic data generated.
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Features of CellKey System

Features and Benefits  

Reliable measurement of endogenous receptors: The CellKey™ System sensitivity allows biorelevant measurements of receptor activity in cell lines and primary cells.   Label free: Expensive tags, dyes, or specialized reagents are not required.   Unique kinetic response data: CellKey™ response profiles directly correlate to receptor mediated signal transduction pathways, thus enabling identification of the underlying mechanism of action of lead compounds.   Universal platform: Single platform and assay methodology measures both G protein-coupled receptors (GPCRs) and tyrosine kinase receptors (TKRs).   Streamlined assay development: Costly and time consuming biological manipulation of cell lines is avoided. Also, single-assay format can be used for multiple receptor types regardless of signal coupling mechanism.   Ease of use: The CellKey™ System is a fully integrated, flexible and intuitive platform.

General Specifications
Depth 23 in
Height28 in
Width 33 in
Weight282 lbs
Additional Specifications

Measurement Principles: Impedance  
Measurement Frequency Range: 1 kHz - 10 MHz  
Assay Type: Homogenous, cell-based  
Measurement Modes: (Simultaneous fluid addition and read) Endpoint and kinetic measurements  
Update Rate: (96-well) 2- or 10-second update rate  
Microplate Formats:  
CellKey™ Standard 96W microtiter plate: 96-well Sciex proprietary cell plate  
Compound plate: 96-well and 384-well compound plates and reservoirs.  
  
Fluidics  
Format: 96 well pipettor head  
Dispense Speed: Adjustable  
Pipettor Height: Adjustable  
Compound Mixing Capability: Yes  
Dispense Volume: 0 - 200 µL  
  
Temperature Range  
Analysis Range: 17-37 °C (Depending on ambient)  
Ambient Range: 15-30 °C  
  
Deck Positions  
Read positions: One  
Compound plate positions: Two  
Tip-loading positions: One  
  
Power Supply: 100 - 120 or 200-240V (self adjusting) 50 or 60 Hz, 630 W consumption

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