Applied Biosystems - 4700 Proteomics Analyzer
A new level of productivity in high-resolution proteomics
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Features of 4700 Proteomics Analyzer
High-productivity protein analysis The Applied Biosystems 4700 Proteomics Analyzer with TOF/TOF™ Optics is the first analyzer designed to meet the scale and scope of the proteomics challenge. The fully automated platform permits the acquisition of information-rich, high-quality MS and MS/MS spectra on a high-throughput, easy-to-use MALDI platform, thereby removing the analysis bottleneck from proteomics experiments.
Multiple workflows The Applied Biosystems 4700 Proteomics Analyzer is flexible enough to support a wide variety of front-end sample preparation methods, such as 1-D and 2-D gels, multi-dimensional liquid chromatography (MDLC), or Applied Biosystems proprietary Isotope Coded Affinity Tag technology, as well as back-end bioinformatics platforms. This flexibility enhances existing workflows, leveraging your current research investments and enabling you to acquire information that was previously inaccessible. The 4700 Proteomics Analyzer is an automated, high-capacity platform that lets you conduct a broad range of studies to better understand the building blocks of life and disease.
A key differentiator: patented TOF/TOF™ optics The unique advantages of the 4700 Proteomics Analyzer stem from its coaxial tandem time-of-flight MS/MS configuration. This exclusive Applied Biosystems design provides high-energy collision-induced dissociation for high-quality fragmentation with important structural information such as immonium ions, side-chain cleavages, and internal fragments. With this new level of structural detail, you can elucidate important posttranslational modifications and handle challenges like leucine/isoleucine differentiation and other complexities within high-resolution proteomics.
The information-rich, consistent fragmentation patterns allow definitive protein identification and extensive characterization of multiple proteins. The large mass range and high-energy fragmentation of the TOF/TOF™ optics also permit you to analyze proteins without prior digestion, simplifying your protocol. The high rep-rate laser and high-speed data acquisition system provide superior sensitivity and dynamic range for successful analysis of important low-copy proteins like transcription factors and protein kinases. Coupling the throughput and ease-of-use of MALDI with MS/MS specificity yields accurate protein identification and extensive structural information at speeds of up to 1,000 samples per hour.
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